Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells

被引:14
作者
Ngoenkam, Jatuporn [1 ]
Paensuwan, Pussadee [2 ]
Wipa, Piyamaporn [1 ]
Schamel, Wolfgang W. A. [3 ,4 ,5 ]
Pongcharoen, Sutatip [6 ]
机构
[1] Naresuan Univ, Fac Med Sci, Dept Microbiol & Parasitol, Phitsanulok, Thailand
[2] Naresuan Univ, Fac Allied Hlth Sci, Dept Optometry, Phitsanulok, Thailand
[3] Univ Freiburg, Signalling Res Ctr BIOSS & CIBSS, Freiburg, Germany
[4] Univ Freiburg, Fac Biol, Dept Immunol, Freiburg, Germany
[5] Univ Freiburg, Freiburg Univ Clin, Ctr Chron Immunodeficiency CCI, Freiburg, Germany
[6] Naresuan Univ, Fac Med, Dept Med, Phitsanulok, Thailand
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
关键词
WASp; T cell signaling; T cell activation; MAPK; PKC; calcium; KINASE-C-THETA; ANTIGEN RECEPTOR; TYROSINE KINASE; PKC-THETA; N-WASP; CYTOSKELETAL REARRANGEMENT; IMMUNOLOGICAL SYNAPSE; ACTIN POLYMERIZATION; GENE-TRANSCRIPTION; ARP2/3; COMPLEX;
D O I
10.3389/fcell.2021.674572
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Signal transduction regulates the proper function of T cells in an immune response. Upon binding to its specific ligand associated with major histocompatibility complex (MHC) molecules on an antigen presenting cell, the T cell receptor (TCR) initiates intracellular signaling that leads to extensive actin polymerization. Wiskott-Aldrich syndrome protein (WASp) is one of the actin nucleation factors that is recruited to TCR microclusters, where it is activated and regulates actin network formation. Here we highlight the research that has focused on WASp-deficient T cells from both human and mice in TCR-mediated signal transduction. We discuss the role of WASp in proximal TCR signaling as well as in the Ras/Rac-MAPK (mitogen-activated protein kinase), PKC (protein kinase C) and Ca2+-mediated signaling pathways.
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页数:9
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