A combination of irinotecanicisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model

被引：21

作者：

Kiyuna, Tasuku ^{[1
,2
,3
]}

Tome, Yasunori ^{[3
]}

Murakami, Takashi ^{[1
,2
]}

Miyake, Kentaro ^{[1
,2
]}

Igarashi, Kentaro ^{[1
,2
]}

Kawaguchi, Kei ^{[1
,2
]}

Oshiro, Hiromichi ^{[1
,2
]}

Higuchi, Takashi ^{[1
,2
]}

Miyake, Masuyo ^{[1
,2
]}

Sugisawa, Norihiko ^{[1
,2
]}

Zhang, Zhiying ^{[1
,2
]}

Razmjooei, Sahar ^{[1
]}

Wangsiricharoen, Sintawat ^{[1
]}

Chmielowski, Bartosz ^{[4
]}

Nelson, Scott D. ^{[5
]}

Russell, Tara A. ^{[6
]}

Dry, Sarah M. ^{[5
]}

Li, Yunfeng ^{[5
]}

Eckardt, Mark A. ^{[7
]}

Singh, Arun S. ^{[4
]}

Chawla, Sant ^{[8
]}

Kanaya, Fuminori ^{[3
]}

Eilber, Fritz C. ^{[6
]}

Singh, Shree Ram ^{[9
]}

Zhao, Ming ^{[1
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] AntiCanc Inc, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[3] Univ Ryukyus, Grad Sch Med, Dept Orthoped Surg, Nishihara, Okinawa, Japan

[4] Univ Calif Los Angeles, Div Hematol Oncol, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90024 USA

[6] Univ Calif Los Angeles, Div Surg Oncol, Los Angeles, CA USA

[7] Yale Sch Med, Dept Surg, New Haven, CT USA

[8] Sarcoma Oncol Ctr, Santa Monica, CA USA

[9] NCI, Basic Res Lab, Frederick, MD 21701 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 505卷 / 03期

关键词：

Myxofibrosarcoma; Patient-derived orthotopic xenograft; S. typhimurium A1-R; Temozolomide; Irinotecan; IRINOTECAN PLUS CISPLATIN; SOFT-TISSUE SARCOMA; PHASE-II TRIAL; NUDE-MICE; ORTHOTOPIC TRANSPLANTATION; RECOMBINANT METHIONINASE; CANCER; CHEMOTHERAPY; RADIOTHERAPY; METASTASIS;

D O I：

10.1016/j.bbrc.2018.09.106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myxofibrosarcoma (MFS) is the most common sarcomas in elderly patients and is either chemo-resistant or recurs with metastasis after chemotherapy. This recalcitrant cancer in need of improved treatment. We have established a patient-derived orthotopic xenograft (PDOX) of MFS. The MFS PDOX model was established in the biceps femoris of nude mice and randomized into 7 groups of 7 mice each: control; doxorubicin (DOX); pazopanib (PAZ); temozolomide (TEM); Irinotecan (IRN); IRN combined with TEM; IRN combined with cisplatinum (CDDP) and Salmonella typhimurium AI-R (S. typhimurium Al-R). Treatment was evaluated by relative tumor volume and relative body weight. The MFS PDOX models were DOX, PAZ, and TEM resistant. IRN combined with TEM and IRN combined with CDDP were most effective on the MFS PDOX. S. typhimurium Al-R arrested the MFS PDOX tumor. There was no significant body weight loss in any group. The present study suggests that the combination of IRN with either TEM or CDDP, and S. typhimurium have clinical potential for MFS. Published by Elsevier Inc.

引用

页码：733 / 739

页数：7

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