Arginine vasopressin and angiotensin II receptor binding inhibition by Atractylodes species

被引：3
|
作者：
Takeda, O
Tsuchiya, K
Kimura, K
Kubo, M
Okada, M
He, SA
机构：
[1] Tsumura & Co, Tsumura Cent Res Labs, Ami, Ibaraki 3001192, Japan
[2] Jiangsu Inst Bot, Nanjing, Peoples R China
来源：
PHARMACEUTICAL BIOLOGY | 2001年 / 39卷 / 03期
关键词：
Atractylodes lancea; angiotensin II; arginine vasopressin; beta-eudesmol; hinesol; receptor binding inhibition; sequiterpenols;
D O I：
10.1076/phbi.39.3.191.5924
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four known sesquiterpenols (beta -eudesmol, hinesol, elemol, alpha -bisabolol) were isolated from the MeOH extract of the dried rhizomes of Atractylodes lancea. These compounds, moderately (IC50,10(-4)-10(-5)M) inhibited the in vitro binding of [H-3]arginine vasopressin and [H-3] angiotensin II to kidney membrane receptors. The MeOH extracts of Atractylodes plants rhizomes varied in antagonistic activity, which correlated with the variation of beta -eudesmol and hinesol.
引用
收藏
页码：191 / 197
页数：7
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