Klebsiella pneumoniae type 3 fimbria-mediated immunity to infection in the murine model of respiratory disease

被引：38

作者：

Lavender, H ^{[1
]}

Jagnow, JJ ^{[1
]}

Clegg, S ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2005年 / 295卷 / 03期

关键词：

Klebsiella pneumoniae; type; 3; fimbriae; immunization; partial protection;

D O I：

10.1016/j.ijmm.2005.04.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Type 3 fimbriae are expressed by most strains of Klebsiella pneumoniae and facilitate adherence to the basement membrane of human respiratory tissues. The ability of these appendages to stimulate a protective immune response in vivo has not been investigated. A murine model of acute pneumonia was used to determine whether the production of type 3 fimbria-specific antibodies correlated with protection against infection by K pneumoniae. Purified fimbriae from several strains were used to immunize mice prior to challenge with a virulent strain. The immunized mice produced high titers of specific antibody and this was associated with protection against challenge with a low dose of bacteria that was lethal in unimmunized animals. However, challenge with a high number of bacteria resulted in no protection against infection. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：153 / 159

页数：7