The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function

被引：8

作者：

Wischhof, Lena ^{[1
]}

Maida, Simona ^{[1
]}

Piazzesi, Antonia ^{[1
]}

Gioran, Anna ^{[1
]}

Sanz, Kristina Barragan ^{[1
,2
]}

Irsen, Stephan ^{[2
]}

Beyer, Marc ^{[1
]}

Schultze, Joachim L. ^{[1
]}

Dyer, Martin J. ^{[3
]}

Salomoni, Paolo ^{[1
]}

Ehninger, Dan ^{[1
]}

Nicotera, Pierluigi ^{[1
]}

Bano, Daniele ^{[1
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[2] Ctr Adv European Studies & Res caesar, Bonn, Germany

[3] Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester, Leics, England

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

欧洲研究理事会;

关键词：

CHROMATIN-REMODELING COMPLEX; BAF MSWI/SNF COMPLEXES; GENE; MUTATIONS; HAPLOINSUFFICIENCY; EXPRESSION; REPRESSION; COMPONENTS; EXCHANGE; DELETION;

D O I：

10.1038/s41598-017-17284-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chromatin remodelers have emerged as prominent regulators of epigenetic processes and potential drivers of various human pathologies. The multi-subunit chromatin-remodeling SWI/SNF complex determines gene expression programs and, consequently, contributes to the differentiation, maturation and plasticity of neurons. Here, we investigate the elusive biological function of Bcl7a and Bcl7b, two newly identified subunits of the SWI/SNF complex that are highly expressed throughout the brain. We generated ubiquitous and neuron-specific Bcl7a and Bcl7b single and double knockout mice. We provide evidence that Bcl7b is dispensable for animal survival as well as behavioral plasticity. Conversely, ubiquitous Bcl7a knockout results in perinatal lethality, while genetic deletion of Bcl7a in postmitotic neurons elicits motor abnormalities and affects dendritic branching of Purkinje cells, with no obvious synergistic relationship with Bcl7b. Collectively, our findings reveal novel insights into the cellular processes linked to BCL7-containing SWI/SNF complexes and their unrecognized roles in the brain.

引用

页数：13

共 51 条

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