Repeated cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy in patients with peritoneal carcinomatosis: A retrospective cohort study

被引：3
作者：
Paasch, C. [1 ]
De Santo, G. [2 ]
Gamal-Eldin, H. N. [3 ]
Huenerbein, M. [4 ]
机构：
[1] Brandenburg Med Univ, Univ Hosp Brandenburg An der Havel, Clin Gen & Visceral Surg, Hochstr 29, D-14770 Brandenburg, Germany
[2] Oberhavel Kliniken Gransee, Dept Gen Surg, Meseberger Weg 12-13, D-16775 Gransee, Brandenburg, Germany
[3] Helios Klinikum Berlin Buck, Ctr Obes & Metab Surg, Schwanebecker Chaussee 50, D-13125 Berlin, Germany
[4] Oberhavel Klin Oranienburg, Dept Surg, Robert Koch Str 2-12, D-16515 Oranienburg, Germany
来源：
ANNALS OF MEDICINE AND SURGERY | 2021年 / 70卷
关键词：
HIPEC; Hyperthermic intraperitoneal chemotherapy; Colorectal cancer; Peritoneal carcinomatosis; Gastric cancer; Peritoneal mesothelioma; CANCER-PATIENTS; SURVIVAL; METASTASES; HIPEC;
D O I：
10.1016/j.amsu.2021.102824
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: The prognosis of abdominal cancer with peritoneal carcinomatosis (PC) is poor. In literature, some authors described a repeated Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in patients with recurrent PC as feasible for overall survival improvement. Hence, we implemented this approach at our hospital and analyzed our cases. Methods: A unicentric retrospective observational study took place at the Helios hospital Berlin-Buch in 2020. The data of individuals who received a HIPEC in the time of 2007-2019 were extracted. The data were entered in the HIPEC database of the German Society of General and Visceral Surgery (StuDoQ vertical bar HIPEC, German society for general and visceral surgery). The primary objective was the overall survival after first HIPEC procedure. Results: A total of 292 data files from were extracted and 14 patients were identified as eligible for further analysis (7x colorectal, 3x gastric, 1x appendix cancer, 1x cancer of unknown primary, 1x Mesothelioma, 1x Pseudomyxoma peritonei). The mean age was 57 (8) years. The BMI was on average 23.5 (3.5) kg/m(2). A total of 8 individuals were female and 6 male (6xASA-Score I, 8xASA-Score II). The initial Peritoneal Cancer Index (PCI) was on average 11.5 (9.1). The average overall survival after 1. HIPEC for colonic cancer was 74 months (n = 3; 43, 70 and 90 month), for gastric cancer 29 months (n = 2; 19 and 39 month) and for mesothelioma 44 months (n = 1). Conclusions: Based on our findings Repeated Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy may improve overall survival of selected patients suffering from peritoneal carcinomatosis.
引用
收藏
页数：6
相关论文
共 18 条
[11]   Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer [J].
Seshadri, Ramakrishnan Ayloor ;
Glehen, Olivier .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (03) :1114-1130
[12]   PROGNOSTIC FEATURES OF 51 COLORECTAL AND 130 APPENDICEAL CANCER-PATIENTS WITH PERITONEAL CARCINOMATOSIS TREATED BY CYTOREDUCTIVE SURGERY AND INTRAPERITONEAL CHEMOTHERAPY [J].
SUGARBAKER, PH ;
JABLONSKI, KA .
ANNALS OF SURGERY, 1995, 221 (02) :124-132
[13]   Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases [J].
van der Geest, Lydia G. M. ;
Lam-Boer, Jorine't ;
Koopman, Miriam ;
Verhoef, Cees ;
Elferink, Marloes A. G. ;
de Wilt, Johannes H. W. .
CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (05) :457-465
[14]   Patterns of metachronous metastases after curative treatment of colorectal cancer [J].
van Gestel, Yvette R. B. M. ;
de Hingh, Ignace H. J. T. ;
van Herk-Sukel, Myrthe P. P. ;
van Erning, Felice N. ;
Beerepoot, Laurens V. ;
Wijsman, Jan H. ;
Slooter, Gerrit D. ;
Rutten, Harm J. T. ;
Creemers, Geert-Jan M. ;
Lemmens, Valery E. P. P. .
CANCER EPIDEMIOLOGY, 2014, 38 (04) :448-454
[15]   Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics [J].
Van Hooser, Alanna ;
Williams, Todd R. ;
Myers, Daniel T. .
ABDOMINAL RADIOLOGY, 2018, 43 (11) :2913-2922
[16]   Repeated cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with recurrent peritoneal carcinomatosis [J].
Vassos, Nikolaos ;
Foertsch, Thomas ;
Aladashvili, Archil ;
Hohenberger, Werner ;
Croner, Roland S. .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2016, 14
[17]   Outcomes of Repeat Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Surface Malignancy [J].
Votanopoulos, Konstantinos I. ;
Ihemelandu, Chukwuemeka ;
Shen, Perry ;
Stewart, John H. ;
Russell, Gregory B. ;
Levine, Edward A. .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2012, 215 (03) :412-417
[18]  
Zoetmulder F A, 1999, Ned Tijdschr Geneeskd, V143, P1863
12