Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

被引：15

作者：

Ha, Wei ^{[2
,3
]}

Meng, Xian-Wei ^{[1
]}

Li, Quan ^{[2
]}

Fan, Min-Min ^{[1
]}

Peng, Shu-Lin ^{[2
]}

Ding, Li-Sheng ^{[2
]}

Tian, Xuan ^{[3
]}

Zhang, Sheng ^{[1
]}

Li, Bang-Jing ^{[2
]}

机构：

[1] Sichuan Univ, State Key Lab Polymer Mat Engn, Polymer Res Inst, Chengdu 610065, Peoples R China

[2] Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

SOFT MATTER | 2011年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

SIZE-EXCLUSION CHROMATOGRAPHY; COIL BLOCK-COPOLYMERS; HUMAN SERUM-ALBUMIN; ALPHA-CYCLODEXTRIN; POLY(ETHYLENE GLYCOL); COMMON SOLVENT; SPHERES; ALGINATE; POLY(EPSILON-CAPROLACTONE); MICELLES;

D O I：

10.1039/c0sm00896f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This paper presents a kind of self-assembled hollow nanosphere for enzyme encapsulation. The enzyme molecules were encapsulated in hollow spheres directly in aqueous solution through the self-assembly of rod-coil Alg-g-PEG and alpha-CDs complexes. These Alg-g-PEG/alpha-CD hollow spheres showed semi-permeability which could prevent big enzyme molecules from leaving while allowing small substrates and products to pass through to maintain the enzyme activity. The permeability properties of Alg-g-PEG/alpha-CD hollow nanospheres were investigated by encapsulating different probes. The results showed that the molar mass cutoff (MMCO) of these hollow nanospheres was between 20 and 40 kDa. The encapsulation capability of Alg-g-PEG/alpha-CD hollow nanospheres was also investigated, the results indicated a maximal values for L-asparaginase encapsulation. Furthermore, the encapsulation behavior for L-asparaginase showed PEG graft density (GD) dependence.

引用

页码：1018 / 1024

页数：7

共 50 条

[21] Self-assembly of gold nanoparticles on fullerene nanospheres
Zhang, P
Li, JX
Liu, DF
Qin, YJ
Guo, ZX
Zhu, DB
LANGMUIR, 2004, 20 (04) : 1466 - 1472
[22] The self-assembly of monodisperse nanospheres within microtubes
Zheng, Yue Bing
Juluri, Bala Krishna
Huang, Tony Jun
NANOTECHNOLOGY, 2007, 18 (27)
[23] Hollow Nanospheres Based on the Self-Assembly of Alginate-graft-poly(ethylene glycol) and α-Cyclodextrin
Meng, Xian-Wei
Ha, Wei
Cheng, Cong
Dong, Zhen-Qiang
Ding, Li-Sheng
Li, Bang-Jing
Zhang, Sheng
LANGMUIR, 2011, 27 (23) : 14401 - 14407
[24] Chemical Synthesis and Self-Assembly of Hollow Ni/Ni2P Hybrid Nanospheres
Zafiropoulou, Irene
Papagelis, Konstantinos
Boukos, Nikos
Siokou, Angeliki
Niarchos, Dimitris
Tzitzios, Vassilios
JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (17): : 7582 - 7585
[25] Self-assembly of an amphiphilic macromolecule under spherical confinement: An efficient route to generate hollow nanospheres
Glagoleva, A. A.
Vasilevskaya, V. V.
Yoshikawa, K.
Khokhlov, A. R.
JOURNAL OF CHEMICAL PHYSICS, 2013, 139 (24):
[26] Self-assembly of poly(o-methoxyaniline) hollow nanospheres from a polymeric acid solution
Sui, Jing
Zhang, Lijuan
Peng, Hui
Travas-Sejdic, Jadranka
Kilmartin, Paul A.
NANOTECHNOLOGY, 2009, 20 (41)
[27] Self-assembly of nanoparticles for encapsulation of actives.
Weitz, DA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U61 - U61
[28] Self-Assembly of Polyamines as a Facile Approach to Fabricate Permeability Tunable Polymeric Shells for Biomolecular Encapsulation
Bai Jianhao
Sebastian, Beyer
Yein, Toh Soo
Dieter, Trau
ACS APPLIED MATERIALS & INTERFACES, 2011, 3 (05) : 1665 - 1674
[29] Synthesis of hollow magnetite nanoparticles via self-assembly and their magnetorheological properties
An, Ji Su
Han, Wen Jiao
Choi, Hyoung Jin
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2017, 535 : 16 - 23
[30] SELF-ASSEMBLY OF MEMBRANE JUNCTIONS
BRUINSMA, R
GOULIAN, M
PINCUS, P
BIOPHYSICAL JOURNAL, 1994, 67 (02) : 746 - 750

← 1 2 3 4 5 →