Easy Synthesis and Ring-Opening Polymerization of 5-Z-Amino-δ-valerolactone New Degradable Amino-Functionalized (Co)polyesters

被引：34

作者：

Blanquer, Sebastien ^{[1
]}

Tailhades, Julien ^{[1
]}

Darcos, Vincent ^{[1
]}

Amblard, Muriel ^{[1
]}

Martinez, Jean ^{[1
]}

Nottelet, Benjamin ^{[1
]}

Coudane, Jean ^{[1
]}

机构：

[1] Univ Montpellier 2, Univ Montpellier 1, IBMM, CNRS,UMR 5247,Fac Pharm, F-34093 Montpellier 5, France

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2010年 / 48卷 / 24期

关键词：

aliphatic polyesters; amino functional polymer; biodegradable; degradable polymers; functionalization of polymers; hydrophilic polymers; lactone synthesis; lactones polyelectrolytes; polyesters; ring opening polymerization; GENE DELIVERY VECTORS; ALIPHATIC POLYESTERS; CHEMICAL-MODIFICATION; EPSILON-CAPROLACTONE; BETA-LACTONES; COPOLYMERS; ROUTE; ACIDS; SERINE; COMPLEXES;

D O I：

10.1002/pola.24400

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel 5 Z amino delta valerolactone (5 NHZ VL) was synthesized with an aim to prepare degradable polyesters and copolyesters having amino pendant groups Following a straightforward and efficient synthetic pathway 5 NHZ VL was obtained in only two steps and up to 50% yield The monomer was fully characterized by H-1 NMR C-13 NMR ESI mass spec trometry and HPLC Various conventional conditions were tested for this lactone ring opening polymerization and led to the novel corresponding poly(5 NHZ VL) (M-n = 7000 g/mol PD = 1 2) Following this homopolymerization 5 NHZ VL was copolymerized with c caprolactone to generate a family of copolyesters with an amino group content ranging from 10 to 80% Finally the polyelectrolyte poly(5 NH3+ VL) was recovered by removal of the protecting group under acidic conditions and integrity of the polyester backbone was confirmed by H-1 NMR (C) 2010 Wiley Periodicals Inc J Polym Sci Part A Polym Chem 48 5891-5898 2010

引用

页码：5891 / 5898

页数：8

共 28 条

[1] A versatile synthetic approach to polypeptide based rod-coil block copolymers by click chemistry [J].