Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion

被引：49
|
作者：
Leidal, Andrew M. [1 ,2 ]
Debnath, Jayanta [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
来源：
FASEB BIOADVANCES | 2021年 / 3卷 / 05期
关键词：
SNCA/ALPHA-SYNUCLEIN RELEASE; LC3-ASSOCIATED PHAGOCYTOSIS; UNCONVENTIONAL SECRETION; CELL BIOLOGY; PATHWAY; PROTEIN; MECHANISMS; MACROAUTOPHAGY; TRANSLOCATION; SENESCENCE;
D O I：
10.1096/fba.2020-00138
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy-related genes (ATGs) in non-degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.
引用
收藏
页码：377 / 386
页数：10
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