Nanoparticles of lipoic acid esters: preparation and antioxidant effect

被引：3
|
作者：
Shchelkonogov, Vasiliy A. [1 ,2 ]
Inshakova, Anna M. [1 ]
Shipelova, Alina, V [1 ]
Baranova, Olga A. [2 ]
Chekanov, Andrey, V [2 ]
Shastina, Natalya S. [1 ]
Solov'eva, Ella Yu [2 ]
Fedin, Anatoly, I [2 ]
机构：
[1] MIREA Russian Technol Univ, MV Lomonosov Inst Fine Chem Technol, Moscow 119571, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia
来源：
MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 04期
关键词：
nanoparticles; lipoic acid esters; neutrophils; reactive oxygen species; phorbol-12-myristate-13-acetate; MECHANISMS;
D O I：
10.1016/j.mencom.2021.07.023
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Five lipoic acid esters were synthesized, and their nanoforms based on copolymer Pluronic F68 and phosphatidylcholine were obtained. The most pronounced antioxidant effect on neutrophils activated by phorbol-12-myristate-13-acetate was shown by the nanodispersion containing the derivative of lipoic acid with hexane-1,6-diol, reducing the concentration of reactive oxygen species by 7.5 times.
引用
收藏
页码：507 / 508
页数：2
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