NVP-AUY922:: A novel small molecule HSP90 inhibitor with potent in vivo antitumor efficacy

被引:0
|
作者
Jensen, Michael Rugaard [1 ]
Schoepfer, Joseph [1 ]
Radimersky, Thomas [1 ]
Massey, Andrew [2 ]
Brueggen, Josef [1 ]
Schweitzer, Alain [3 ]
Pfaar, Ulrike [3 ]
Ruetz, Stephan [1 ]
Guy, Chantal [4 ]
Buckler, Alan [4 ]
Schnell, Christian [1 ]
Cozens, Robert [1 ]
Brough, Paul [2 ]
Drysdale, Martin [2 ]
Quadt, Cornelia [3 ]
Garcia-Echeverria, Carlos [1 ]
Chene, Patrick [1 ]
机构
[1] Novartis Inst BioMed Res, Basel, Switzerland
[2] Vernalis Ltd, Cambridge, England
[3] Novartis Pharma AG, Basel, Switzerland
[4] Novartis Inst BioMed Res, Cambridge, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3521S / 3521S
页数:1
相关论文
共 50 条
  • [41] Pharmakokinetic/phamacodynamic relationship of the HSP90 inhibitor NVP-AUY922 in human xenografts and patients in a clinical Phase I trial
    Jensen, Michael
    Ide, Susan
    Brueggen, Josef
    Schoepfer, Joseph
    Wang, Xiaofeng
    Quadt, Cornelia
    Garcia-Echeverria, Carlos
    CANCER RESEARCH, 2009, 69
  • [42] Novel HSP90 Inhibitor NVP-AUY922 Enhances the Anti-tumor Effect of Temsirolimus Against Oral Squamous Cell Carcinoma
    Okui, Tatsuo
    Shimo, Tsuyoshi
    Fukazawa, Takuya
    Hassan, Nur Mohammad Monsur
    Honami, Tatsuki
    Ibaragi, Soichiro
    Takaoka, Munenori
    Naomoto, Yoshio
    Sasaki, Akira
    CURRENT CANCER DRUG TARGETS, 2013, 13 (03) : 289 - 299
  • [43] Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitize tumor cell lines under acute hypoxia
    Blassl, C.
    Djuzenova, C. S.
    Katzer, A.
    Tripp, C.
    Roloff, K.
    Bernhard, M.
    Flentje, M.
    Jensen, M. R.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2010, 186 : 74 - 74
  • [44] 2-phenylethynesulphonamide (PFT-) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels
    Yeramian, Andree
    Vea, Alvar
    Benitez, Sandra
    Ribera, Joan
    Domingo, Monica
    Santacana, Maria
    Martinez, Montserrat
    Maiques, Oscar
    Valls, Joan
    Dolcet, Xavier
    Vilella, Ramon
    Cabiscol, Elisa
    Matias-Guiu, Xavier
    Marti, Rosa M.
    PIGMENT CELL & MELANOMA RESEARCH, 2016, 29 (03) : 352 - 371
  • [45] Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922
    He, Chun-Xia
    Lv, You
    Guo, Meng
    Zhou, Huan
    Qin, Wei
    Zhao, Dong
    Li, Hui-Jin
    Xing, Lu
    Zhou, Xin
    Li, Peng-Quan
    Yu, Feng
    He, Jian-Hua
    Cao, Hui-Ling
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [46] The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib
    Park, Kang-Seo
    Oh, Bora
    Lee, Mi-Hee
    Nam, Ky-Youb
    Jin, Hae Ran
    Yang, Hannah
    Choi, Junyoung
    Kim, Sang -We
    Lee, Dae Ho
    CANCER LETTERS, 2016, 372 (01) : 75 - 81
  • [47] The Hsp90 inhibitor, NVP-AUY922, produces anti-tumour activity through inhibition of fibronectin polymerization resulting in cytoskeletal reorganization
    Armstrong, Heather
    Butler, Lisa
    Selth, Luke
    Tarulli, Gerard
    Centenera, Margaret
    BJU INTERNATIONAL, 2015, 116 : 39 - 39
  • [48] Activity of new heat shock protein 90 (hsp90) inhibitor NVP-AUY922 against myeloma cells sensitive and resistant to conventional agents
    McMillin, Douglas W.
    Negri, Joseph
    Delmore, Jake
    Hayden, Patrick
    Ooi, Melissa
    Mitsiades, Nicholas
    Schlossman', Robert
    Richardson, Paul G.
    Munshi, Nikhil C.
    Jensen, Michael R.
    Quadt, Cornelia
    Chene, Patrick
    Schoepfer, Joseph
    Garcia-Echeverria, Carlos
    Anderson, Kenneth C.
    Mitsiades, Constantine S.
    BLOOD, 2007, 110 (11) : 474A - 474A
  • [49] The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells
    Alexandra Canonici
    Zulfiqar Qadir
    Neil T. Conlon
    Denis M. Collins
    Neil A. O’Brien
    Naomi Walsh
    Alex J. Eustace
    Norma O’Donovan
    John Crown
    Investigational New Drugs, 2018, 36 : 581 - 589
  • [50] The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells
    Canonici, Alexandra
    Qadir, Zulfiqar
    Conlon, Neil T.
    Collins, Denis M.
    O'Brien, Neil A.
    Walsh, Naomi
    Eustace, Alex J.
    O'Donovan, Norma
    Crown, John
    INVESTIGATIONAL NEW DRUGS, 2018, 36 (04) : 581 - 589