Mesoporous radiosensitized nanoprobe for enhanced NIR-II photoacoustic imaging-guided accurate radio-chemotherapy

被引：30

作者：

Chen, Tao ^{[1
]}

Su, Lichao ^{[1
]}

Lin, Lisen ^{[1
]}

Ge, Xiaoguang ^{[1
]}

Bai, Feicheng ^{[1
]}

Niu, Meng ^{[1
]}

Wang, Chenlu ^{[1
]}

Song, Jibin ^{[1
]}

Guo, Shaolei ^{[2
]}

Yang, Huanghao ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China

[2] Sun Yat Sen Univ, Dept Neurosurg, Affiliated Hosp 1, Guangzhou 510080, Peoples R China

来源：

NANO RESEARCH | 2022年 / 15卷 / 05期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

radiotherapy; second near infrared window (NIR-II); photoacoustic imaging; tumor hypoxia; photocatalysis; PHOTOCATALYST; SEMICONDUCTOR; NANOPARTICLES; RADIOTHERAPY; NANOSPHERES;

D O I：

10.1007/s12274-021-3997-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics, and developing the oxygen production nanoplatforms received the widespread attention. However, it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy. Herein, we present a novel theranostics nanoplatform (Au NPs/UCNPs/WO3@C) comprising of tungsten trioxide (WO3) that loaded gold nanoparticles (Au NPs) and up-conversion nanoparticles (UCNPs) for improved photoacoustic (PA) imaging performance in the second near infrared window (NIR-II, 900-1,700 nm). Au NPs/UCNPs/WO3@C exhibited superior oxygen-generation effect and doxorubicin loading capacity, thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Importantly, the accumulated Au NPs/UCNPs/WO3@C in the tumor region led to the increased NIR-II PA imaging signal and the blood oxygen saturation signal, which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues. This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO3@C for NIR-II PA imaging-guided tumor therapeutics.

引用

页码：4154 / 4163

页数：10

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