A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

被引：1
作者：
Lopez-Prado, Maria Victoria [1 ]
Sabater, Maria J. [1 ]
Corma, Avelino [1 ]
机构：
[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Ave Naranjos S-N, E-46022 Valencia, Spain
来源：
PETROLEUM CHEMISTRY | 2020年 / 60卷 / 04期
关键词：
CALCIUM-CHANNEL BLOCKERS; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; ACID-ESTERS; EFFICIENT SYNTHESIS; REUSABLE CATALYST; SOLID CATALYST; ZEOLITE; SOLVENT; IDENTIFICATION; HYDROGENATION;
D O I：
10.1134/S0965544120040106
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical(TM)) analogue-based therapies has a 3,4-dihydropyrimidin-2(1H)-one (DHPM) scaffold and was obtained by means of a three one-pot process through successive oxidation, cyclocondensation and transesterification reactions. The one-pot strategy was extended to the synthesis of a series of related ester DHPM derivatives.
引用
收藏
页码：499 / 507
页数：9
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