Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease

被引:290
|
作者
Wang, Baohong [1 ]
Jiang, Xiangyang [1 ]
Cao, Min [1 ]
Ge, Jianping [1 ]
Bao, Qiongling [1 ]
Tang, Lingling [1 ]
Chen, Yu [1 ]
Li, Lanjuan [1 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 1, Natl Collaborat Innovat Ctr Diag & Treatment Infe, State Key Lab Diag & Treatment Infect Dis,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
基金
中国国家自然科学基金;
关键词
SERUM ANTIOXIDANT CAPACITY; GUT MICROBIOTA; URIC-ACID; METABOLIC SIGNIFICANCE; INTESTINAL MICROBIOTA; RISK-FACTORS; PREVALENCE; POPULATION; OBESE; STEATOHEPATITIS;
D O I
10.1038/srep32002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Increasing evidence suggests a role of intestinal dysbiosis in obesity and non-alcoholic fatty liver disease (NAFLD). But it remains unknown in nonobese NAFLD. This prospective, cross-sectional study sought to characterize differences in fecal microbiota between nonobese adult individuals with and without NAFLD and their potential association with metabolic markers of disease progression. A total of 126 nonobese subjects were enrolled: 43 NAFLD and 83 healthy controls (HC). The microbial community was profiled by denaturing gradient gel electrophoresis and examined by 454 pyrosequencing of the 16S ribosomal RNA V3 region. Lower diversity and a phylum-level change in the fecal microbiome were found in NAFLD. Compared with HC, patients had 20% more phylum Bacteroidetes (p = 0.005) and 24% less Firmicutes (p = 0.002). Within Firmicutes, four families and their 8 genera, which were short-chain fatty acids-producing and 7 alpha-dehydroxylating bacteria, were significantly decreased. Moreover, Gramnegative (G-) bacteria were prevalent in NAFLD (p = 0.008). Furthermore, a significant correlation with metabolic markers was revealed for disturbed microbiota in NAFLD. This novel study indicated that intestinal dysbiosis was associated with nonobese NAFLD and might increase the risk of NAFLD progression.
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页数:11
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