Quorum Sensing Inhibitors of Staphylococcus aureus from Italian Medicinal Plants

被引：41

作者：

Quave, Cassandra L. ^{[1
]}

Plano, Lisa R. W. ^{[2
]}

Bennett, Bradley C. ^{[1
]}

机构：

[1] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA

[2] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

来源：

PLANTA MEDICA | 2011年 / 77卷 / 02期

关键词：

quorum sensing; MRSA; medicinal plants; delta-toxin; delta-hemolysin; agr; MULTIDRUG EFFLUX PUMPS; VIRULENCE; ANTIBACTERIAL; INFECTIONS; RESISTANCE; ALBANIANS; ARBERESHE; TARGET; MRSA;

D O I：

10.1055/s-0030-1250145

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Morbidity and mortality estimates due to methicillin-resistant Staphylococcus aureus (MRSA) infections continue to rise. Therapeutic options are limited by antibiotic resistance. Anti-pathogenic compounds, which inhibit quorum sensing (QS) pathways, may be a useful alternative to antibiotics. Staphylococcal QS is encoded by the agr locus and is responsible for the production of delta-hemolysin. Quantification of delta-hemolysin found in culture supernatants permits the analysis of agr activity at the translational rather than transcriptional level. We employed reversed phase high performance chromatographic (RP-HPLC) techniques to investigate the anti-QS activity of 168 extracts from 104 Italian plants through quantification of delta-hemolysin. Extracts from three medicinal plants (Ballota nigra, Castanea sativa, and Sambucus ebulus) exhibited a dose-dependent response in the production of delta-hemolysin, indicating anti-QS activity in a pathogenic MRSA isolate.

引用

页码：188 / 195

页数：8

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