The versatility of Shigella effectors

被引：116
作者：
Ogawa, Michinaga [1 ]
Honda, Yutaka [1 ]
Ashida, Hiroshi [1 ]
Suzuki, Masato [1 ]
Sasakawa, Chihiro [1 ,2 ,3 ]
机构：
[1] Univ Tokyo, Dept Microbiol & Immunol, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan
[2] Univ Tokyo, Dept Infect Dis Control, Inst Med Sci, Int Res Ctr Infect Dis,Minato Ku, Tokyo 1088639, Japan
[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan
来源：
NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 01期
基金：
日本科学技术振兴机构;
关键词：
D O I：
10.1038/nrmicro1814
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
When Shigella infect the intestinal epithelium, they deliver several effectors through the type III secretion system (T3SS) into the surrounding space and directly into the host-cell. cytoplasm, where they can mimic and usurp host cellular functions or subvert host-cell signalling pathways and the immune response. Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection.
引用
收藏
页码：11 / 16
页数：6
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