Meropenem/colistin versus meropenem/ampicillin-sulbactam in the treatment of carbapenem-resistant pneumonia

被引：30
作者：
Khalili, Hossein [1 ]
Shojaei, Lida [2 ]
Mohammadi, Mostafa [3 ]
Beigmohammadi, Mohammad-Taghi [3 ]
Abdollahi, Alireza [4 ]
Doomanlou, Mahsa [5 ]
机构：
[1] Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran
[2] Kermanshah Univ Med Sci, Fac Pharm, Dept Clin Pharm, Kermanshah, Iran
[3] Univ Tehran Med Sci, Imam Khomeini Hosp, Fac Med, Dept Intens Care Unit, Tehran, Iran
[4] Univ Tehran Med Sci, Imam Khomeini Hosp, Fac Med, Dept Pathol, Tehran, Iran
[5] Univ Tehran Med Sci, Cent Lab, Imam Hosp Complex, Tehran, Iran
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2018年 / 7卷 / 09期
关键词：
Acinetobacter; ampicillin-sulbactam; colistin; pneumonia; VENTILATOR-ASSOCIATED PNEUMONIA; ACINETOBACTER-BAUMANNII; NOSOCOMIAL PNEUMONIA; AMPICILLIN-SULBACTAM; INTRAVENOUS COLISTIN; RISK-FACTORS; POLYMYXIN-B; MORTALITY; SURVEILLANCE; INFECTIONS;
D O I：
10.2217/cer-2018-0037
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Aim: Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A. baumannii. Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A. baumannii. Method: 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A. baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days. Clinical and microbiological responses and 28-day mortality were considered as outcomes. Results: Clinical response (75 vs 69.6%; p = 0.75) and microbial eradication (87.50 vs 91.3%; p = 0.59) were comparable between meropenem/colistin and meropenem/ampicillin-sulbactam groups, respectively. Conclusion: In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups.
引用
收藏
页码：901 / 911
页数：11
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