Meropenem/colistin versus meropenem/ampicillin-sulbactam in the treatment of carbapenem-resistant pneumonia

被引：30
作者：
Khalili, Hossein [1 ]
Shojaei, Lida [2 ]
Mohammadi, Mostafa [3 ]
Beigmohammadi, Mohammad-Taghi [3 ]
Abdollahi, Alireza [4 ]
Doomanlou, Mahsa [5 ]
机构：
[1] Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran
[2] Kermanshah Univ Med Sci, Fac Pharm, Dept Clin Pharm, Kermanshah, Iran
[3] Univ Tehran Med Sci, Imam Khomeini Hosp, Fac Med, Dept Intens Care Unit, Tehran, Iran
[4] Univ Tehran Med Sci, Imam Khomeini Hosp, Fac Med, Dept Pathol, Tehran, Iran
[5] Univ Tehran Med Sci, Cent Lab, Imam Hosp Complex, Tehran, Iran
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2018年 / 7卷 / 09期
关键词：
Acinetobacter; ampicillin-sulbactam; colistin; pneumonia; VENTILATOR-ASSOCIATED PNEUMONIA; ACINETOBACTER-BAUMANNII; NOSOCOMIAL PNEUMONIA; AMPICILLIN-SULBACTAM; INTRAVENOUS COLISTIN; RISK-FACTORS; POLYMYXIN-B; MORTALITY; SURVEILLANCE; INFECTIONS;
D O I：
10.2217/cer-2018-0037
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Aim: Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A. baumannii. Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A. baumannii. Method: 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A. baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days. Clinical and microbiological responses and 28-day mortality were considered as outcomes. Results: Clinical response (75 vs 69.6%; p = 0.75) and microbial eradication (87.50 vs 91.3%; p = 0.59) were comparable between meropenem/colistin and meropenem/ampicillin-sulbactam groups, respectively. Conclusion: In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups.
引用
收藏
页码：901 / 911
页数：11
相关论文
共 46 条
  • [1] Ventilator-associated pneumonia in a teaching hospital in Tehran and use of the Iranian Nosocomial Infections Surveillance software
    Afhami, Sh
    Hadadi, A.
    Khorami, E.
    Seifi, A.
    Bazaz, N. Esmailpour
    [J]. EASTERN MEDITERRANEAN HEALTH JOURNAL, 2013, 19 (10) : 883 - 887
  • [2] Incidence and predictors of 14-day mortality in multidrug-resistant Acinetobacter baumannii in ventilator-associated pneumonia
    Almomani, Basima A.
    McCullough, Amanda
    Gharaibeh, Rawan
    Samrah, Shaher
    Mahasneh, Fatimah
    [J]. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2015, 9 (12): : 1323 - 1330
  • [3] [Anonymous], MULT RES ORG CLOSTR
  • [4] In Vitro Activities of Tigecycline, Minocycline, and Colistin-Tigecycline Combination against Multi- and Pandrug-Resistant Clinical Isolates of Acinetobacter baumannii Group
    Arroyo, Luis A.
    Mateos, Ingeborg
    Gonzalez, Veronica
    Aznar, Javier
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (03) : 1295 - 1296
  • [5] Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia
    Betrosian, Alex P.
    Frantzeskaki, Frantzeska
    Xanthaki, Anna
    Douzinas, Emmanuel E.
    [J]. JOURNAL OF INFECTION, 2008, 56 (06) : 432 - 436
  • [6] High-dose ampicillin-sulbactam as an alternative treatment of late-onset VAP from multidrug-resistant Acinetobacter baumannii
    Betrosian, Alex P.
    Frantzeskaki, Frantzeska
    Xanthaki, Anna
    Georgiadis, George
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2007, 39 (01) : 38 - 43
  • [7] Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections
    Betrosian, Alex P.
    Douzinas, Emmanuel E.
    [J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2009, 5 (09) : 1099 - 1112
  • [8] Pharmacological and Patient-Specific Response Determinants in Patients with Hospital-Acquired Pneumonia Treated with Tigecycline
    Bhavnani, Sujata M.
    Rubino, Christopher M.
    Hammel, Jeffrey P.
    Forrest, Alan
    Dartois, Nathalie
    Cooper, C. Angel
    Korth-Bradley, Joan
    Ambrose, Paul G.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (02) : 1065 - 1072
  • [9] Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies
    Cai, Yun
    Chai, Dong
    Wang, Rui
    Liang, Beibei
    Bai, Nan
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (07) : 1607 - 1615
  • [10] Ventilator associated pneumonia: comparison between quantitative and qualitative cultures of tracheal aspirates
    Camargo, LFA
    De Marco, FV
    Barbas, CSV
    Hoelz, C
    Bueno, MAS
    Rodrigues, M
    Amado, VM
    Caserta, R
    Martino, MD
    Pasternak, J
    Knobel, E
    [J]. CRITICAL CARE, 2004, 8 (06): : R422 - R430
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