Antiretroviral drugs for tuberculosis control in the era of HIV/AIDS

被引：173

作者：

Williams, BG ^{[1
]}

Dye, C ^{[1
]}

机构：

[1] WHO, Communicable Dis, CH-1211 Geneva 27, Switzerland

来源：

SCIENCE | 2003年 / 301卷 / 5639期

关键词：

D O I：

10.1126/science.1086845

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/ AIDS) has dramatically increased the incidence of tuberculosis (TB) in sub-Saharan Africa, where up to 60% of TB patients are coinfected with HIV and each year 200,000 TB deaths are attributable to HIV coinfection. Now HIV threatens control of TB in Asia, Eastern Europe, and Latin America. Antiretroviral ( ARV) drugs can prevent TB by preserving immunity, but cohort analysis shows that early therapy, plus high levels of coverage and compliance, will be needed to avert a significant fraction of TB cases. However, ARV drugs could enhance the treatment of TB, and TB programs provide an important entry point for the treatment of HIV/ AIDS.

引用

页码：1535 / 1537

页数：3

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