Spectrophotometric methods for the determination of ampicillin by potassium permanganate and 1-chloro-2,4-dinitrobenzene in pharmaceutical preparations

被引:20
|
作者
Khan, Aftab Aslam Parwaz [1 ,4 ]
Mohd, Ayaz [3 ,4 ]
Bano, Shaista [4 ]
Siddiqi, K. S. [4 ]
Asiri, Abdullah Mohammed [1 ,2 ]
机构
[1] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Fac Sci, Jeddah, Saudi Arabia
[2] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah, Saudi Arabia
[3] Univ Putra Malaysia, Dept Chem & Environm Engn, Fac Engn, Serdang 43400, Selangor, Malaysia
[4] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India
关键词
Kinetic determination; Ampicillin; Potassium permanganate; 1-Chloro-2,4-dinitrobenzene; POLAROGRAPHIC-DETERMINATION; COMPLEX-FORMATION; PENICILLINS; CEPHALOSPORINS; ANTIBIOTICS; AMOXICILLIN;
D O I
10.1016/j.arabjc.2012.04.033
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two simple and sensitive kinetic methods for the determination of ampicillin (AMP) are described. The first method is based on kinetic investigation of the oxidation reaction of the drug with alkaline potassium permanganate at room temperature for a fixed time of 25 min. The absorbance of the colored manganate ions is measured at 610 nm. The second method is based on the reaction of AMP with 1-chloro-2,4-dinitrobenzene (CDNB) in the presence of 0.1 mol L-1 sodium bicarbonate. Spectrophotometric measurement was achieved by recording the absorbance at 490 nm for a fixed time of 60 min. All variables affecting the development of the color were investigated and the conditions were optimized. Plots of absorbance against concentration in both procedures were rectilinear over the ranges 5-30 and 50-260 mu g mL(-1), with mean recoveries 99.80 and 99.91, respectively. The proposed methods were successfully applied for the determination of AMP in bulk powder and in capsule dosage form. The determination of AMP by the fixed concentration method is feasible with the calibration equations obtained, but the fixed time method proves to be more applicable. (C) 2012 Production and hosting by Elsevier B. V. on behalf of King Saud University.
引用
收藏
页码:255 / 263
页数:9
相关论文
共 50 条
  • [41] Study of the 1-chloro-2,4-dinitrobenzene + oh- reaction in tetradecyltrimethylammonium bromide aqueous micellar solutions
    María del Mar Graciani
    Amalia Rodríguez
    María Muñoz
    María Luisa Moyá
    Reaction Kinetics and Catalysis Letters, 2003, 78 (1): : 113 - 119
  • [42] ENZYME-SPECIFIC INHIBITION OF HUMAN GLUTATHIONE TRANSFERASES BY NAPHTHALENE ANALOGUES OF 1-CHLORO-2,4-DINITROBENZENE
    Groom, Hilary
    Lee, Moses
    Josephy, P. David
    DRUG METABOLISM REVIEWS, 2014, 45 : 129 - 129
  • [43] GLUTATHIONE-DEPENDENT TOXICITY OF THE ALGICIDE 1-CHLORO-2,4-DINITROBENZENE TO DAPHNIA-MAGNA STRAUS
    DIERICKX, PJ
    VANDERWIELEN, C
    BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1986, 37 (04) : 629 - 632
  • [44] SELECTIVE DETECTION OF FRUCTOSE AND SUCROSE BY MEANS OF 1-CHLORO-2,4-DINITROBENZENE AND ION-EXCHANGE RESIN
    QURESHI, SZ
    ANWAR, S
    FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1979, 298 (01): : 46 - 46
  • [45] N-acetylcysteine and clotrimazole inhibit sickle erythrocyte dehydration induced by 1-chloro-2,4-dinitrobenzene
    Shartava, A
    Shah, AK
    Goodman, SR
    AMERICAN JOURNAL OF HEMATOLOGY, 1999, 62 (01) : 19 - 24
  • [46] EFFECT OF CROWN ETHERS ON THE REACTIVITY OF ALKOXIDES .1. THE REACTION OF POTASSIUM METHOXIDE WITH 1-CHLORO-2,4-DINITROBENZENE IN METHANOL-BENZENE MIXTURES
    MARIANI, C
    MODENA, G
    SCORRANO, G
    JOURNAL OF CHEMICAL RESEARCH-S, 1978, (10): : 392 - &
  • [47] ANION-EXCHANGE DETECTION AND SPECTROPHOTOMETRIC DETERMINATION OF SOME REDUCING SUGARS WITH 1-CHLORO 2,4-DINITROBENZENE
    QURESHI, PM
    SINGH, SB
    KHAN, IA
    ANNALI DI CHIMICA, 1989, 79 (1-2) : 73 - 79
  • [48] GLUTATHIONE CONJUGATION WITH 1-CHLORO-2,4-DINITROBENZENE (CDNB) - INTERINDIVIDUAL VARIABILITY IN HUMAN LIVER, LUNG, KIDNEY AND INTESTINE
    TEMELLINI, A
    CASTIGLIONI, M
    GIULIANI, L
    MUSSI, A
    GIULIANOTTI, PC
    PIETRABISSA, A
    ANGELETTI, CA
    MOSCA, F
    PACIFICI, GM
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 1995, 33 (09) : 498 - 503
  • [49] Effect of Glucagon-Like Peptide 2 on Hepatic, Renal, and Intestinal Disposition of 1-Chloro-2,4-dinitrobenzene
    Villanueva, Silvina S. M.
    Perdomo, Virginia G.
    Ruiz, Maria L.
    Rigalli, Juan P.
    Arias, Agostina
    Luquita, Marcelo G.
    Vore, Mary
    Catania, Viviana A.
    Mottino, Aldo D.
    DRUG METABOLISM AND DISPOSITION, 2012, 40 (07) : 1252 - 1258
  • [50] TEMPERATURE DEPENDENCE OF CHLORINE NUCLEAR QUADRUPOLE RESONANCE IN 1,3,5-TRICHLOROBENZENE AND 1-CHLORO-2,4-DINITROBENZENE
    VIJAYA, MS
    RAMAKRISHNA, J
    MOLECULAR PHYSICS, 1970, 19 (01) : 131 - +