Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy

被引：9
作者：
Yuan, Yanbing [1 ]
Chen, Ning [1 ]
Wang, Luyao [1 ]
Zhang, Xuedian [2 ]
Chen, Hui [1 ]
Ma, Pei [1 ]
机构：
[1] Univ Shanghai Sci & Technol, Coll Opt & Comp Engn, Shanghai Key Lab Modern Opt Syst, Shanghai 200093, Peoples R China
[2] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China
来源：
ANALYTICAL SCIENCES | 2022年 / 38卷 / 02期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Surface-enhanced Raman spectroscopy; Nanoparticles; Chinese traditional patent medicine; Nifedipine; Illegal addition; SERS DETECTION; SILVER NANOPARTICLES; GOLD NANOSTRUCTURES; SENSITIVE DETECTION; HEALTH FOODS; ANIMAL URINE; SCATTERING; SUBSTRATE; HYPERTENSION; CLENBUTEROL;
D O I：
10.2116/analsci.21P148
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Nifedipine is an antihypertensive chemical. The illegal addition of this chemical into Chinese traditional patent medicine (CTPM) is unstandardized and lacks regulation. It could bring serious side effects to patients, causing various symptoms. Therefore, accurate detection of nifedipine is very important for human health and the prevention of illegal additives. Surface-enhanced Raman spectroscopy (SERS) is a fast and sensitive fingerprint spectroscopic technique, which has been shown to be promising in drug detection. In this study, nifedipine in CTPM was determined qualitatively and quantitatively with SERS. Linear relationships between the concentrations of nifedipine and the intensities of the characteristic peaks were established. The results showed a linear relationship within the concentration range of 0.5-10 mg/L, and the lowest detectable concentration of nifedipine in CTPM was 0.1 mg/L (equivalent to 0.03% doping of nifedipine in CTPM). This method has shown a great potential in the detection of drugs illegally added to CTPM.
引用
收藏
页码：359 / 368
页数：10
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