Is intraindividual reaction time variability an independent cognitive predictor of mortality in old age? Findings from the Sydney Memory and Ageing Study

被引:25
作者
Kochan, Nicole A. [1 ,2 ]
Bunce, David [1 ,3 ]
Pont, Sarah [1 ]
Crawford, John D. [1 ]
Brodaty, Henry [1 ,4 ]
Sachdev, Perminder S. [1 ,2 ]
机构
[1] UNSW, Sch Psychiat, Ctr Hlth Brain Ageing CHeBA, Sydney, NSW, Australia
[2] Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia
[3] Univ Leeds, Fac Med & Hlth, Sch Psychol, Leeds, W Yorkshire, England
[4] UNSW Australia, Sch Psychiat, DCRC ABC, Sydney, NSW, Australia
基金
英国医学研究理事会;
关键词
MINI-MENTAL-STATE; ALL-CAUSE; DEMENTIA; IMPAIRMENT; COMMUNITY; ADULTS; ASSOCIATION; PERFORMANCE; INCONSISTENCY; FRAMINGHAM;
D O I
10.1371/journal.pone.0181719
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Intraindividual variability of reaction time (IIVRT), a proposed cognitive marker of neurobiological disturbance, increases in old age, and has been associated with dementia and mortality. The extent to which IIVRT is an independent predictor of mortality, however, is unclear. This study investigated the association of IIVRT and all-cause mortality while accounting for cognitive level, incident dementia and biomedical risk factors in 861 participants aged 70-90 from the Sydney Memory and Ageing Study. Participants completed two computerised reaction time (RT) tasks (76 trials in total) at baseline, and comprehensive medical and neuropsychological assessments every 2 years. Composite RT measures were derived from the two tasks-the mean RT and the IIVRT measure computed from the intraindividual standard deviation of the RTs (with age and time-on-task effects partialled out). Consensus dementia diagnoses were made by an expert panel of clinicians using clinical criteria, and mortality data were obtained from a state registry. Cox proportional hazards models estimated the association of IIVRT and mean RT with survival time over 8 years during which 191 (22.2%) participants died. Greater IIVRT but not mean RT significantly predicted survival time after adjusting for age, sex, global cognition score, cardiovascular risk index and apolipoprotein epsilon 4 status. After excluding incident dementia cases, the association of IIVRT with mortality changed very little. Our findings suggest that greater IIVRT uniquely predicts shorter time to death and that lower global cognition and prodromal dementia in older individuals do not explain this relationship.
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页数:11
相关论文
共 49 条
[1]  
American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders: DSM-5, V5th ed, DOI 10.1176/appi.books.9780890425596
[2]   Effects of sociodemographic and health variables on Mini-Mental State Exam scores in older Australians [J].
Anderson, Tracy M. ;
Sachdev, Perminder S. ;
Brodaty, Henry ;
Trollor, Julian N. ;
Andrews, Gavin .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2007, 15 (06) :467-476
[3]  
[Anonymous], 2001, Boston naming test
[4]   Intra-individual reaction time variability and all-cause mortality over 17 years: a community-based cohort study [J].
Batterham, Philip J. ;
Bunce, David ;
Mackinnon, Andrew J. ;
Christensen, Helen .
AGE AND AGEING, 2014, 43 (01) :84-90
[5]  
Benton AL, 1996, BENTON TEST
[6]   Intraindividual Variability Is a Fundamental Phenomenon of Aging: Evidence From an 8-Year Longitudinal Study Across Young, Middle, and Older Adulthood [J].
Bielak, Allison A. M. ;
Cherbuin, Nicolas ;
Bunce, David ;
Anstey, Kaarin J. .
DEVELOPMENTAL PSYCHOLOGY, 2014, 50 (01) :143-151
[7]   Intraindividual Variability in Reaction Time Predicts Cognitive Outcomes 5 Years Later [J].
Bielak, Allison A. M. ;
Hultsch, David F. ;
Strauss, Esther ;
MacDonald, Stuart W. S. ;
Hunter, Michael A. .
NEUROPSYCHOLOGY, 2010, 24 (06) :731-741
[8]   Intraindividual Variability Is Related to Cognitive Change in Older Adults: Evidence for Within-Person Coupling [J].
Bielak, Allison A. M. ;
Hultsch, David F. ;
Strauss, Esther ;
MacDonald, Stuart W. S. ;
Hunter, Michael A. .
PSYCHOLOGY AND AGING, 2010, 25 (03) :575-586
[9]   Dementia time to death: a systematic literature review on survival time and years of life lost in people with dementia [J].
Brodaty, Henry ;
Seeher, Katrin ;
Gibson, Louisa .
INTERNATIONAL PSYCHOGERIATRICS, 2012, 24 (07) :1034-1045
[10]   Inconsistency in serial choice decision and motor reaction times dissociate in younger and older adults [J].
Bunce, D ;
MacDonald, SWS ;
Hultsch, DF .
BRAIN AND COGNITION, 2004, 56 (03) :320-327