Improved synergetic therapy efficiency of cryoablation and nanoparticles for MCF-7 breast cancer

被引：4

作者：

Ye, Ping ^{[1
]}

Yin, Haitao ^{[2
]}

Gu, Xuelian ^{[1
]}

Ye, Yuanyuan ^{[3
]}

Zhao, Qingxiao ^{[1
]}

Chang, Zhaohua ^{[1
]}

Han, Baosan ^{[3
]}

Chen, Xiaoxiang ^{[4
]}

Liu, Peifeng ^{[5
]}

机构：

[1] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai Inst Minimally Invas Therapy, Shanghai 200093, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Ophthalmol, Shanghai 200127, Peoples R China

[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gen Surg, Shanghai 200092, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Rheumatol, Shanghai 200127, Peoples R China

[5] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai Canc Inst,State Key Lab Oncogenes & Rela, Shanghai 200032, Peoples R China

来源：

NANOMEDICINE | 2018年 / 13卷 / 15期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

breast cancer; cryoablation; doxorubicin; nanoparticles; therapy efficiency; MPEG-PLGA-PLL; LOCALIZED PROSTATE-CANCER; RADIOFREQUENCY ABLATION; TARGETED DELIVERY; CELLULAR UPTAKE; MANAGEMENT; PET/CT;

D O I：

10.2217/nnm-2018-0168

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Current cryoablation therapy easily induces a high tumor recurrence, it is therefore necessary to develop an effective method to enhance its antitumor efficacy. Materials & methods: We solve the aforementioned problem by introducing doxorubicin (DOX) loading methoxy polyethylene glycol-polylactic-co-glycolic acid-poly-L-lysine-cyclic arginine-glycine-aspartic acid peptide nanoparticles (DOX nanoparticles) in the process of cryoablation. Results: The combination of cryoablation and DOX nanoparticles greatly decreases the recurrence rate of breast cancer, which is owing to the specific targeting therapy of DOX nanoparticles for residuary breast cancer cells after cryoablation. Therefore, the survival time of MCF-7 breast cancer bearing mice significantly increases. Conclusion: The synergetic therapy of cryoablation and DOX nanoparticles is an effective therapy means for breast cancer. This strategy provides new means for treating breast cancer.

引用

页码：1889 / 1903

页数：15

共 30 条

[1] Issues critical to the successful application of cryosurgical ablation of the prostate [J].