Associations of prenatal exposure to five chlorophenols with adverse birth outcomes

被引:36
作者
Guo, Jianqiu [1 ]
Wu, Chunhua [1 ]
Lv, Shenliang [1 ,2 ]
Lu, Dasheng [1 ,2 ]
Feng, Chao [2 ]
Qi, Xiaojuan [1 ,3 ]
Liang, Weijiu [4 ]
Chang, Xiuli [1 ]
Xu, Hao [4 ]
Wang, Guoquan [2 ]
Zhou, Zhijun [1 ]
机构
[1] Fudan Univ, Collaborat Innovat Ctr Social Risks Governance Hl, Key Lab Publ Hlth Safety, Sch Publ Hlth,Minist Educ, 130 Dongan Rd, Shanghai 200032, Peoples R China
[2] Shanghai Municipal Ctr Dis Control & Prevent, 1380 Zhongshan West Rd, Shanghai 200336, Peoples R China
[3] Zhejiang Prov Ctr Dis Control & Prevent, 3399 Binsheng Rd, Hangzhou 310051, Zhejiang, Peoples R China
[4] Shanghai Ctr Dis Control & Prevent, 39 Yunwushan Rd, Shanghai 200051, Peoples R China
基金
中国国家自然科学基金;
关键词
Chlorophenols; Prenatal exposure; Birth outcomes; Newborns; Urine; DISINFECTION BY-PRODUCTS; URINARY CONCENTRATIONS; PREGNANT-WOMEN; AMNIOTIC-FLUID; IN-VITRO; PENTACHLOROPHENOL; PHENOLS; WATER; RISK; 2,4,6-TRICHLOROPHENOL;
D O I
10.1016/j.envpol.2016.04.074
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposures to chlorophenols (CPs) have been linked with adverse health effects on wildlife and humans. This study aimed to evaluate prenatal exposure to five CP compounds using maternal urinary concentrations during pregnancy and the potential associations with birth outcomes of their infants at birth. A total of 1100 mother-newborn pairs were recruited during June 2009 to January 2010 in an agricultural region, China. Urinary concentrations of five CPs from dichlorophenol (DCP) to pentachlorophenol (PCP), namely, 2,5-DCP, 2,4-DCP, 2,4,5-trichlorophenol (2,4,5-TCP), 2,4,6-TCP and PCP, were measured using large-volume-injection gas chromatography-tandem mass spectrometry (LVI-GC-MS-MS), and associations between CP levels and weight, length as well as head circumference at birth were examined. Median urinary creatinine-adjusted concentrations of 2,5-DCP, 2,4-DCP, 2,4,5-TCP, 2,4,6-TCP and PCP were 3.34 mu g/g, 1.03 mu g/g, < LOD, 1.78 mu g/g and 0.39 mu g/g creatinine, respectively. We found lower birth weight 30 g [95% confidence interval (CI): -57, -3; p = 0.03] for per SD increase in logio-transformed concentrations of 2,4,6-TCP and lower birth weight 37 g (95% CI: -64, -10; p = 0.04) for PCP, respectively. Similarly, head circumference decrease in associations with creatinine-corrected 2,4,6-TCP and PCP concentrations were also achieved. Considering sex difference, the associations of lower birth weight were only found among male neonates, while head circumference was associated with 2,4-DCP and 2,5-DCP only found among female neonates. This study showed significant negative associations between CPs exposure and reduction in neonatal anthropometric measures. The biological mechanisms concerning CPs exposure on fetal growth deserved further investigations. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:478 / 484
页数:7
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