Bullous pemphigoid and neurodegenerative diseases: a study in a setting of a Central European university dermatology department

被引：26

作者：

Pietkiewicz, Pawel ^{[1
]}

Gornowicz-Porowska, Justyna ^{[1
]}

Bowszyc-Dmochowska, Monika ^{[2
]}

Bartkiewicz, Pawel ^{[1
]}

Dmochowski, Marian ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Dermatol, Autoimmune Blistering Dermatoses Sect, 49 Przybyszewski St, PL-60355 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Dermatol, Cutaneous Histopathol & Immunopathol Sect, Poznan, Poland

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2016年 / 28卷 / 04期

关键词：

Bullous pemphigoid; Neurodegenerative diseases; Aging; ASSOCIATION;

D O I：

10.1007/s40520-015-0459-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Bullous pemphigoid (BP) is an autoimmune blistering dermatosis of the elderly mediated by IgG and IgE antibodies to skin hemidesmosomal proteins, BP180 and/or BP230, that occur physiologically also in neuronal tissue. It was reported that BP is associated with neurodegenerative diseases (ND). We performed a retrospective study in a setting of a Central European university dermatology department on prevalence of ND in 94 BP patients. 26 out of 94 BP patients had at least one ND. ND included: Parkinson's disease, dementia, stroke, hear loss, tinnitus, blindness, vertigo, neurosyphilis, systemic sclerosis, and epilepsy. Since population aging is conceivably responsible for the rising number of BP cases as a result of immunosenescence-related phenomena, the plausible BP-specific immunopathogenetic relationship between BP and ND deserves to be further experimentally explored.

引用

页码：659 / 663

页数：5

共 28 条

[1] A population-based study of the association between bullous pemphigoid and neurologic disorders [J].