An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to assist in the diagnosis of Pneumocystis pneumonia

被引：15

作者：

White, P. Lewis ^{[1
]}

Posso, Raquel B. ^{[2
]}

Gorton, Rebecca L. ^{[3
]}

Price, Jessica S. ^{[1
]}

Wey, E. ^{[3
]}

Barnes, Rosemary A. ^{[2
]}

机构：

[1] Publ Hlth Wales, Microbiol Cardiff, UK Clin Mycol Network UKCMN Reg Mycol Reference L, Cardiff, S Glam, Wales

[2] Cardiff Univ, Sch Med, Infect Immun & Biochem, Cardiff, S Glam, Wales

[3] UKCMN Reg Lab, Dept Microbiol, Hlth Serv Labs, London, England

来源：

MEDICAL MYCOLOGY | 2018年 / 56卷 / 06期

关键词：

beta-D-glucan; Pneumocystis pneumonia; Dynamiker Fungus Assay; BETA-D-GLUCAN; INVASIVE ASPERGILLOSIS; JIROVECII PNEUMONIA; METAANALYSIS; ACCURACY;

D O I：

10.1093/mmy/myx097

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Dynamiker (R) Fungus (1-3)-beta-D-Glucan Assay (D-BDG) has recently become available in the Western Hemisphere for the diagnosis of invasive fungal disease (IFD). Evaluations of its performance for Pneumocystis pneumonia (PcP) are limited. A retrospective evaluation of D-BDG diagnosis of PcP was performed (23 PcP cases and 23 controls). Sensitivity and specificity were 87% and 70%, respectively, reducing the positivity threshold to 45 pg/ml increased sensitivity (96%), whereas a threshold of 300 pg/ml increased specificity (96%). The performance of D-BDG for the detection of PcP is comparable to other IFD, but sensitivity is below that required to confidently exclude PcP.

引用

页码：778 / 781

页数：4

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