Cytoskeletal control of B cell responses to antigens

被引:96
作者
Tolar, Pavel [1 ,2 ]
机构
[1] Francis Crick Inst, Immune Receptor Activat Lab, 1 Midland Rd, London NW1 1AT, England
[2] Imperial Coll London, Div Immunol & Inflammat, Hammersmith Campus,Cane Rd, London W12 0NN, England
基金
欧洲研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词
WISKOTT-ALDRICH-SYNDROME; SYNDROME PROTEIN-DEFICIENCY; FOLLICULAR DENDRITIC CELLS; T-CELL; ACTIN CYTOSKELETON; N-WASP; IMMUNOLOGICAL-SYNAPSE; MARGINAL ZONE; LYMPHOCYTE-ACTIVATION; SIGNALING MOLECULES;
D O I
10.1038/nri.2017.67
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to B cell receptor (BCR) signalling pathways, and defects of the actin cytoskeleton can either promote or suppress B cell activation. Recent insights from studies using single-cell imaging and biophysical techniques suggest that actin orchestrates BCR signalling at the plasma membrane through effects on protein diffusion and that it regulates antigen discrimination through the biomechanics of immune synapses. These mechanical functions also have a role in the adaptation of B cell subsets to specialized tasks during antibody responses.
引用
收藏
页码:621 / 634
页数:14
相关论文
共 180 条
  • [1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
    Abdul-Manan, N
    Aghazadeh, B
    Liu, GA
    Majumdar, A
    Ouerfelli, O
    Siminovitch, KA
    Rosen, MK
    [J]. NATURE, 1999, 399 (6734) : 379 - 383
  • [2] Imaging of germinal center selection events during affinity maturation
    Allen, Christopher D. C.
    Okada, Takaharu
    Tang, H. Lucy
    Cyster, Jason G.
    [J]. SCIENCE, 2007, 315 (5811) : 528 - 531
  • [3] WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
    Antón, IM
    de la Fuente, MA
    Sims, TN
    Freeman, S
    Ramesh, N
    Hartwig, JH
    Dustin, ML
    Geha, RS
    [J]. IMMUNITY, 2002, 16 (02) : 193 - 204
  • [4] Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation
    Arana, Eloisa
    Vehlow, Anne
    Harwood, Naomi E.
    Vigorito, Elena
    Henderson, Robert
    Turner, Martin
    Tybulewicz, Victor L. J.
    Batista, Facundo D.
    [J]. IMMUNITY, 2008, 28 (01) : 88 - 99
  • [5] Imaging techniques for assaying lymphocyte activation in action
    Balagopalan, Lakshmi
    Sherman, Eilon
    Barr, Valarie A.
    Samelson, Lawrence E.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2011, 11 (01) : 21 - 33
  • [6] Asymmetric B Cell Division in the Germinal Center Reaction
    Barnett, Burton E.
    Ciocca, Maria L.
    Goenka, Radhika
    Barnett, Lisa G.
    Wu, Junmin
    Laufer, Terri M.
    Burkhardt, Janis K.
    Cancro, Michael P.
    Reiner, Steven L.
    [J]. SCIENCE, 2012, 335 (6066) : 342 - 344
  • [7] Mechanical Communication at the Immunological Synapse
    Basu, Roshni
    Huse, Morgan
    [J]. TRENDS IN CELL BIOLOGY, 2017, 27 (04) : 241 - 254
  • [8] Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing
    Basu, Roshni
    Whitlock, Benjamin M.
    Husson, Julien
    Le Floc'h, Audrey
    Jin, Weiyang
    Oyler-Yaniv, Alon
    Dotiwala, Farokh
    Giannone, Gregory
    Hivroz, Claire
    Biais, Nicolas
    Lieberman, Judy
    Kam, Lance C.
    Huse, Morgan
    [J]. CELL, 2016, 165 (01) : 100 - 110
  • [9] B cells extract and present immobilized antigen: implications for affinity discrimination
    Batista, FD
    Neuberger, NS
    [J]. EMBO JOURNAL, 2000, 19 (04) : 513 - 520
  • [10] Varying label density allows artifact-free analysis of membrane-protein nanoclusters
    Baumgart, Florian
    Arnold, Andreas M.
    Leskovar, Konrad
    Staszek, Kaj
    Foelser, Martin
    Weghuber, Julian
    Stockinger, Hannes
    Schuetz, Gerhard J.
    [J]. NATURE METHODS, 2016, 13 (08) : 661 - +