Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease

被引：258

作者：

Yasojima, K ^{[1
]}

Schwab, C ^{[1
]}

McGeer, EG ^{[1
]}

McGeer, PL ^{[1
]}

机构：

[1] Univ British Columbia, Dept Psychiat, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada

来源：

BRAIN RESEARCH | 2000年 / 887卷 / 01期

关键词：

pentraxin; pyramidal neuron; hippocampus; entorhinal cortex; liver; cerebellum; Western blot; in situ hybridization; mRNA; immunohistochemistry;

D O I：

10.1016/S0006-8993(00)02970-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

C-reactive protein (CRP) and amyloid P (AP) are pentraxins which are associated with many pathological lesions, including the amyloid deposits and neurofibrillary tangles (NFTs) of Alzheimer disease (AD). It has always been assumed that they are generated by liver and delivered to their sites of action by serum. Here we report by in situ hydridization, reverse transcriptase-polymerase chain reaction analysis, Western blotting and immunohistochemistry that the mRNAs and proteins of both CRP and AP are concentrated in pyramidal neurons and are upregulated in affected areas of AD brain. Controlling pentraxin production at the tissue level may be important in reducing inflammatory damage in AD. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：80 / 89

页数：10

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