Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

被引：30

作者：

Yatim, Nader ^{[1
,2
]}

Boussier, Jeremy ^{[3
]}

Tetu, Pauline ^{[2
]}

Smith, Nikaia ^{[1
]}

Bruel, Timothee ^{[4
,5
]}

Charbit, Bruno ^{[6
]}

Barnabei, Laura ^{[7
]}

Corneau, Aurelien ^{[8
]}

Da Meda, Laetitia ^{[2
]}

Allayous, Clara ^{[2
]}

Baroudjian, Barouyr ^{[2
]}

Jebali, Majdi ^{[2
]}

Herms, Florian ^{[2
]}

Grzelak, Ludivine ^{[4
]}

Staropoli, Isabelle ^{[4
]}

Calmettes, Vincent ^{[9
]}

Hadjadj, Jerome ^{[7
,10
]}

Peyrony, Olivier ^{[11
]}

Cassius, Charles ^{[2
]}

LeGoff, Jerome ^{[12
]}

Kramkimel, Nora ^{[9
]}

Aractingi, Selim ^{[9
]}

Fontes, Magnus ^{[13
]}

Blanc, Catherine ^{[8
]}

Rieux-Laucat, Frederic ^{[7
]}

Schwartz, Olivier ^{[4
,5
]}

Terrier, Benjamin ^{[10
]}

Duffy, Darragh ^{[1
,6
]}

Lebbe, Celeste ^{[2
]}

机构：

[1] Inst Pasteur, Dept Immunol, Translat Immunol Lab, F-75015 Paris, France

[2] Univ Paris, Hop St Louis, AP HP, DMU ICARE,INSERM U 976,Dermatol Dept, Paris, France

[3] Sorbonne Univ, Hop St Antoine, AP HP, F-75012 Paris, France

[4] CNRS, Inst Pasteur, Dept Virol, Virus & Immun Unit,UMR 3569, Paris, France

[5] Vaccine Res Inst, Creteil, France

[6] Inst Pasteur, Cytometry & Biomarkers UTechS, CRT, F-75015 Paris, France

[7] Univ Paris, INSERM, Lab Immunogenet Pediatr Autoimmune Dis, Imagine Inst,UMR 1163, F-75015 Paris, France

[8] Sorbonne Univ, Fac Med, Plateforme Cytometrie Pitie Salpetriere CyPS, PASS,UMS037, F-75013 Paris, France

[9] Univ Paris, Hop Cochin, AP HP, Dept Dermatol, Paris, France

[10] Univ Paris, Hop Cochin, AP HP, Ctr APHP CUP,Dept Internal Med,Natl Referral Ctr, F-75014 Paris, France

[11] Hop St Louis, AP HP, Emergency Dept, Paris, France

[12] Univ Paris, Hop St Louis, AP HP, Equipe INSIGHT,U976,Virol,INSERM, F-75010 Paris, France

[13] Inst Roche, Boulogne, France

来源：

SCIENCE ADVANCES | 2021年 / 7卷 / 34期

关键词：

COVID-19; CANCER; SEPSIS; SAFETY;

D O I：

10.1126/sciadv.abg4081

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The COVID-19 pandemic has spread worldwide, yet the role of antiviral T cell immunity during infection and the contribution of immune checkpoints remain unclear. By prospectively following a cohort of 292 patients with melanoma, half of which treated with immune checkpoint inhibitors (ICIs), we identified 15 patients with acute or convalescent COVID-19 and investigated their transcriptomic, proteomic, and cellular profiles. We found that ICI treatment was not associated with severe COVID-19 and did not alter the induction of inflammatory and type I interferon responses. In-depth phenotyping demonstrated expansion of CD8 effector memory T cells, enhanced T cell activation, and impaired plasmablast induction in ICI-treated COVID-19 patients. The evaluation of specific adaptive immunity in convalescent patients showed higher spike (S), nucleoprotein (N), and membrane (M) antigen-specific T cell responses and similar induction of spike-specific antibody responses. Our findings provide evidence that ICI during COVID-19 enhanced T cell immunity without exacerbating inflammation.

引用

页数：13

共 50 条

[21] Immunity to SARS-CoV-2 induced by infection or vaccination [J].

Castro Dopico, Xaquin ;

Ols, Sebastian ;

Lore, Karin ;

Karlsson Hedestam, Gunilla B. .

JOURNAL OF INTERNAL MEDICINE, 2022, 291 (01) :32-50

[22] Persistent cellular immunity to SARS-CoV-2 infection [J].

Breton, Gaelle ;

Mendoza, Pilar ;

Hagglof, Thomas ;

Oliveira, Thiago Y. ;

Schaefer-Babajew, Dennis ;

Gaebler, Christian ;

Turroja, Martina ;

Hurley, Arlene ;

Caskey, Marina ;

Nussenzweig, Michel C. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (04)

[23] Immunoglobulin A response to SARS-CoV-2 infection and immunity [J].

Esmat, Khaleqsefat ;

Jamil, Baban ;

Kheder, Ramiar Kaml ;

Kombe, Arnaud John Kombe ;

Zeng, Weihong ;

Ma, Huan ;

Jin, Tengchuan .

HELIYON, 2024, 10 (01)

[24] Role of antiviral CD8+T cell immunity to SARS-CoV-2 infection and vaccination [J].

Karl, Vivien ;

Hofmann, Maike ;

Thimme, Robert .

JOURNAL OF VIROLOGY, 2025, 99 (04)

[25] Breakthrough SARS-COV-2 infection induces broad anti-viral T cell immunity [J].

Lineburg, Katie Eireann ;

Crooks, Pauline ;

Raju, Jyothy ;

Texier, Laetitia Le ;

Khaledi, Panteha ;

Berry, Kiana ;

Swaminathan, Srividhya ;

Panikkar, Archana ;

Rehan, Sweera ;

Guppy-Coles, Kristyan ;

Neller, Michelle Anne ;

Khanna, Rajiv ;

Smith, Corey .

ISCIENCE, 2023, 26 (12)

[26] Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection [J].

Behura, Assirbad ;

Naik, Lincoln ;

Patel, Salina ;

Das, Mousumi ;

Kumar, Ashish ;

Mishra, Abtar ;

Nayak, Dev Kiran ;

Manna, Debraj ;

Mishra, Amit ;

Dhiman, Rohan .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2023, 1869 (03)

[27] Association of immune checkpoint inhibitors with SARS-CoV-2 infection rate and prognosis in patients with solid tumors: a systematic review and meta-analysis [J].

Sun, Lin ;

Zhao, Fangmin ;

Xiang, Yuying ;

Chen, Shuyi ;

Shu, Qijin .

FRONTIERS IN IMMUNOLOGY, 2024, 15

[28] Prognostic impacts of soluble immune checkpoint regulators and cytokines in patients with SARS-CoV-2 infection [J].

Lee, Nuri ;

Jeong, Seri ;

Jeon, Kibum ;

Park, Min-Jeong ;

Song, Wonkeun .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[29] Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection [J].

Coelho, Ana R. ;

Oliveira, Paulo J. .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2020, 50 (10)

[30] Review of studies on SARS-CoV-2 infection inhibitors [J].

Michalski, Aleksander ;

Wojcicka, Patrycja ;

Bielawska-Drozd, Agata ;

Bartoszcze, Michal .

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE, 2021, 28 (04) :541-550

← 1 2 3 4 5 →