High throughput detection chain for time domain optical mammography

被引:23
作者
Ferocino, Edoardo [1 ]
Martinenghi, Edoardo [1 ]
Dalla Mora, Alberto [1 ]
Pifferi, Antonio [1 ,2 ]
Cubeddu, Rinaldo [1 ]
Taroni, Paola [1 ,2 ]
机构
[1] Politecn Milan, Dept Phys, Piazza Leonardo Vinci 32, I-20133 Milan, Italy
[2] Ist Foton & Nanotecnol, CNR, Piazza Leonardo Vinci 32, Milan, Italy
来源
BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 02期
关键词
BREAST-CANCER;
D O I
10.1364/BOE.9.000755
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A novel detection chain, based on 8 Silicon Photomultipliers (forming a wide-area custom-made detection probe) and on a time-to-digital converter, was developed to improve the signal level in multi-wavelength (635-1060 nm) time domain optical mammography. The performances of individual components and of the overall chain were assessed using established protocols (BIP and MEDPHOT). The photon detection efficiency was improved by up to 3 orders of magnitude, and the maximum count rate level was increased by a factor of 10 when compared to the previous system, based on photomultiplier tubes and conventional time-correlated single-photon counting boards. In the estimate of optical parameters, the novel detection chain provides performances comparable to the previous system, widely validated in clinics, but with higher signal level, higher robustness, and at a lower price per channel, thus targeting important requirements for clinical applications. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码:755 / 770
页数:16
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