Colorectal cancers choosing sides

被引：51

作者：

Albuquerque, Cristina ^{[2
]}

Bakker, Elvira R. M. ^{[1
]}

van Veelen, Wendy ^{[1
]}

Smits, Ron ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Gastroenterol & Hepatol, NL-3015 CE Rotterdam, Netherlands

[2] Inst Portugues Oncol Francisco Gentil, CIPM, P-1099023 Lisbon, Portugal

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 02期

关键词：

Wnt/beta-catenin signalling; Colorectal cancer; APC; Mismatch repair; Tumour location; Signalling dosage; ADENOMATOUS POLYPOSIS-COLI; NUCLEAR BETA-CATENIN; ALTERNATIVE GENETIC PATHWAYS; MUTATION CLUSTER REGION; WNT SIGNALING PATHWAY; SOMATIC MUTATIONS; MISMATCH-REPAIR; MICROSATELLITE INSTABILITY; APC MUTATIONS; MOUSE MODEL;

D O I：

10.1016/j.bbcan.2011.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in beta-catenin signalling. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：219 / 231

页数：13

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