Cobalt(III)-Catalyzed [4+2] Annulation of N-Chlorobenzamides with Maleimides

被引：71

作者：

Muniraj, Nachimuthu ^{[1
]}

Prabhu, Kandikere Ramaiah ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 04期

关键词：

C-H ACTIVATION; RING-OPENING REACTIONS; CARBOXYLIC-ACIDS; DIRECTING GROUP; DERIVATIVES; FUNCTIONALIZATION; ALKYLATION; BOND; 1,4-ADDITION; BENZAMIDES;

D O I：

10.1021/acs.orglett.8b04117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Co(III)-catalyzed novel [4 + 2] annulation of N-chlorobenzamides with maleimides has been reported. Mostly, maleimides are known to furnish the Michael-type or 1,1-type cyclized products while treating with amides. In this reaction, maleimides furnished [4 + 2] annulated products in good yields at room temperature while being treated with the internal oxidizing N-chlorobenzamide as a directing group. The developed methodology is compatible with a variety of functional groups. The [4 + 2] annulated products obtained are featured in some biologically active molecules.

引用

页码：1068 / 1072

页数：5

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