Lack of effect of D2 dopamine receptor TaqI A polymorphism on smoking cessation

被引：22

作者：

Berlin, I

Covey, LS

Jiang, HP

Hamer, D

机构：

[1] GHU Pitie Salpetriere, Dept Pharmacol, F-75013 Paris, France

[2] Columbia Univ, New York State Psychiat Inst, Smoking Cessat Clin, New York, NY USA

[3] NIH, Biochem Lab, NCI, Bethesda, MD 20892 USA

来源：

NICOTINE & TOBACCO RESEARCH | 2005年 / 7卷 / 05期

关键词：

D O I：

10.1080/14622200500259176

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

One previous report (Cinciripini et al., [2004] Nicotine & Tobacco Research, 6, 229-239) found that the D2 dopamine receptor (DRD2) TaqI A polymorphism was associated with smoking cessation: Carriers of the Al allele were less likely to quit than were those who were not carriers. If confirmed, this finding would allow one to use precessation genotyping to predict the likelihood of successful quitting. The present study reports on results of a similar smoking cessation study and uses the same methods and data analysis in a larger number of smokers. It fails to replicate the effect of DRD2 TaqI A polymorphism on smoking cessation.

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收藏

页码：725 / 728

页数：4

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