PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription

被引：250

作者：

Beck, David B. ^{[1
]}

Oda, Hisanobu ^{[2
,3
]}

Shen, Steven S. ^{[1
,4
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA

[2] Kyushu Natl Canc Ctr, Gastrointestinal & Med Oncol Div, Fukuoka 8111395, Japan

[3] Kyushu Univ, Dept Immunobiol & Neurosci, Med Inst Bioregulat, Fukuoka 8128582, Japan

[4] NYU, Sch Med, Dept Biochem, Ctr Hlth Informat & Bioinformat, New York, NY 10016 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PR-Set7; H4K20me1; chromatin; cell cycle; DNA damage; H4; LYSINE; 20; DNA-DAMAGE RESPONSE; HISTONE METHYLTRANSFERASE SET8; DOUBLE-STRAND BREAKS; TUMOR SUPPRESSION; GENE-EXPRESSION; SCREEN REVEALS; AURORA-B; IN-VIVO; METHYLATION;

D O I：

10.1101/gad.177444.111

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.

引用

页码：325 / 337

页数：13

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