Intuitive pharmacogenetics: spontaneous risperidone dosage is related to CYP2D6, CYP3A5 and ABCB1 genotypes

被引：38
作者：
Mas, S. [1 ,2 ]
Gasso, P. [1 ,2 ]
Alvarez, S. [1 ,2 ]
Parellada, E. [2 ,3 ]
Bernardo, M. [2 ,3 ,4 ]
Lafuente, A. [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Pathol Anat Pharmacol & Microbiol, IDIBAPS, E-08036 Barcelona, Spain
[2] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain
[3] Hosp Clin Barcelona, Psychiat Serv, Barcelona, Spain
[4] Univ Barcelona, Dept Psychiat & Clin Psychobiol, E-08036 Barcelona, Spain
来源：
PHARMACOGENOMICS JOURNAL | 2012年 / 12卷 / 03期
关键词：
pharmacogenetics; risperidone; CYP2D6; CYP3A5; ABCB1; dose titration; P-GLYCOPROTEIN; ASTERISK-6; POLYMORPHISMS; EXTRAPYRAMIDAL SYMPTOMS; 9-HYDROXYRISPERIDONE; ANTIPSYCHOTICS; PHENOTYPE; CYP2D6-ASTERISK-3; ANTIDEPRESSANTS; SCHIZOPHRENIA; METABOLISM;
D O I：
10.1038/tpj.2010.91
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study is to evaluate whether the quantitative prescription of risperidone (dosage) is related to the patient's metabolic status. Metabolic status was defined in terms of the most relevant polymorphisms of CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3A) and ABCB1 (G2677T) determined a posteriori and blinded to the clinicians. This prospective and observational study includes a cohort of 151 Caucasian psychiatric patients treated with risperidone. Significant differences (Kruskal-Wallis test p = 0.01) among the doses administered were observed to correlate (Spearman's r = 1, p = 0.02) with the different CYP2D6 groups. Poor metabolizers received the lowest doses and ultra rapid metabolizers the highest. No significant correlations were observed with regard to CYP3A5 and ABCB1. We find that, despite not knowing patients' metabolic status, clinicians modify risperidone dosage in order to obtain the best therapeutic option. The Pharmacogenomics Journal (2012) 12, 255-259; doi: 10.1038/tpj.2010.91; published online 21 December 2010
引用
收藏
页码：255 / 259
页数：5
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