Review of pharmacological effects of Glycyrrhiza sp and its bioactive compounds

被引：939

作者：

Asl, Marjan Nassiri ^{[1
]}

Hosseinzadeh, Hossein ^{[1
]}

机构：

[1] Qazvin Univ Med Sci, Fac Med, Dept Pharmacol, Qazvin, Iran

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 06期

关键词：

Glycyrrhiza glabra; glycyrrhizin; glabridin; glycyrrhitinic acid; isoliquiritigenin;

D O I：

10.1002/ptr.2362

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：709 / 724

页数：16

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