Modulation of multidrug resistance by cepharanthine in fresh human gastrointestinal tumor cells

被引：0

作者：

Hotta, T ^{[1
]}

Tanimura, H ^{[1
]}

Yamaue, H ^{[1
]}

Iwahashi, M ^{[1
]}

Tani, M ^{[1
]}

Tsunoda, T ^{[1
]}

Tamai, M ^{[1
]}

Noguchi, K ^{[1
]}

Mizobata, S ^{[1
]}

Arii, K ^{[1
]}

Terasawa, H ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT SURG 2,WAKAYAMA 640,JAPAN

来源：

ONCOLOGY | 1997年 / 54卷 / 02期

关键词：

multidrug resistance; P-glycoprotein; doxorubicin; cepharanthine;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance (MDR) gene. Cepharanthine (CEP) has been shown to circumvent multidrug resistance in P-glycoprotein-expressing cell lines. In the present study, we investigated the augmentation of DOX sensitivity by CEP using an MTT assay, and assessed the correlation between DOX sensitivity and P-glycoprotein expression by flow cytometry, in highly purified fresh human tumor cells obtained from 73 cancer patients. DOX sensitivity was decreased in proportion to P-glycoprotein expression. The cytotoxicity of DOX was increased by CEP in tumor cells possessing low DOX P-glycoprotein sensitivity. Moreover, there was a significant correlation between the effect of Doxorubicin CEP on cytotoxicity and P-glycoprotein expression. Thus, CEP might be able Cepharanthine to circumvent DOX resistance in cancer patients.

引用

页码：153 / 157

页数：5

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