Modulation of multidrug resistance by cepharanthine in fresh human gastrointestinal tumor cells

被引：0

作者：

Hotta, T ^{[1
]}

Tanimura, H ^{[1
]}

Yamaue, H ^{[1
]}

Iwahashi, M ^{[1
]}

Tani, M ^{[1
]}

Tsunoda, T ^{[1
]}

Tamai, M ^{[1
]}

Noguchi, K ^{[1
]}

Mizobata, S ^{[1
]}

Arii, K ^{[1
]}

Terasawa, H ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT SURG 2,WAKAYAMA 640,JAPAN

来源：

ONCOLOGY | 1997年 / 54卷 / 02期

关键词：

multidrug resistance; P-glycoprotein; doxorubicin; cepharanthine;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance (MDR) gene. Cepharanthine (CEP) has been shown to circumvent multidrug resistance in P-glycoprotein-expressing cell lines. In the present study, we investigated the augmentation of DOX sensitivity by CEP using an MTT assay, and assessed the correlation between DOX sensitivity and P-glycoprotein expression by flow cytometry, in highly purified fresh human tumor cells obtained from 73 cancer patients. DOX sensitivity was decreased in proportion to P-glycoprotein expression. The cytotoxicity of DOX was increased by CEP in tumor cells possessing low DOX P-glycoprotein sensitivity. Moreover, there was a significant correlation between the effect of Doxorubicin CEP on cytotoxicity and P-glycoprotein expression. Thus, CEP might be able Cepharanthine to circumvent DOX resistance in cancer patients.

引用

页码：153 / 157

页数：5

共 50 条

[31] Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides
Stewart, AJ
Canitrot, Y
Baracchini, E
Dean, NM
Deeley, RG
Cole, SPC
BIOCHEMICAL PHARMACOLOGY, 1996, 51 (04) : 461 - 469
[32] Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro
Hoffmann, Katrin
Xiao, Zhi
Franz, Clemens
Mohr, Elvira
Serba, Susanne
Buechler, Markus W.
Schemmer, Peter
CANCER CELL INTERNATIONAL, 2011, 11
[33] PSC 833 modulation of multidrug resistance to paclitaxel in cultured human ovarian carcinoma cells leads to apoptosis
Duraj, J
Sedlak, J
Bies, J
Chovancova, J
Chorvath, B
ANTICANCER RESEARCH, 2002, 22 (6A) : 3425 - 3428
[34] Transport proteins of the ABC family and multidrug resistance of tumor cells
Stavrovskaya, A. A.
Stromskaya, T. P.
BIOCHEMISTRY-MOSCOW, 2008, 73 (05) : 592 - 604
[35] YB-1 Protein and Multidrug Resistance of Tumor Cells
Stavrovskaya, Alla
Stromskaya, Tatyana
Rybalkina, Ekaterina
Moiseeva, Natalia
Vaiman, Andrey
Guryanov, Sergey
Ovchinnikov, Lev
Guens, Gelena
CURRENT SIGNAL TRANSDUCTION THERAPY, 2012, 7 (03) : 237 - 246
[36] Transport proteins of the ABC family and multidrug resistance of tumor cells
A. A. Stavrovskaya
T. P. Stromskaya
Biochemistry (Moscow), 2008, 73 : 592 - 604
[37] Cepharanthine hydrochloride reverses P-glycoprotein-mediated multidrug resistance in human ovarian carcinoma A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway
Huang, Chen-Zheng
Wang, Ya-Feng
Zhang, Yan
Peng, You-Mei
Liu, Yi-Xian
Ma, Fang
Jiang, Jin-Hua
Wang, Qing-Duan
ONCOLOGY REPORTS, 2017, 38 (04) : 2558 - 2564
[38] Effect of block architecture on the ability of polyalkylene oxides to overcome multidrug resistance of tumor cells
Pavlov, D. N.
Alexandrova, N. A.
Krylova, O. O.
Pohl, P.
Melik-Nubarov, N. S.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2006, 16 (04) : 259 - 265
[39] Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro
Katrin Hoffmann
Zhi Xiao
Clemens Franz
Elvira Mohr
Susanne Serba
Markus W Büchler
Peter Schemmer
Cancer Cell International, 11
[40] MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS
ABE, Y
NAKAMURA, M
OHNISHI, Y
INABA, M
UEYAMA, Y
TAMAOKA, N
INTERNATIONAL JOURNAL OF ONCOLOGY, 1994, 5 (06) : 1285 - 1292

← 1 2 3 4 5 →