Modulation of multidrug resistance by cepharanthine in fresh human gastrointestinal tumor cells

被引：0
|
作者：
Hotta, T [1 ]
Tanimura, H [1 ]
Yamaue, H [1 ]
Iwahashi, M [1 ]
Tani, M [1 ]
Tsunoda, T [1 ]
Tamai, M [1 ]
Noguchi, K [1 ]
Mizobata, S [1 ]
Arii, K [1 ]
Terasawa, H [1 ]
机构：
[1] WAKAYAMA MED COLL,DEPT SURG 2,WAKAYAMA 640,JAPAN
来源：
ONCOLOGY | 1997年 / 54卷 / 02期
关键词：
multidrug resistance; P-glycoprotein; doxorubicin; cepharanthine;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance (MDR) gene. Cepharanthine (CEP) has been shown to circumvent multidrug resistance in P-glycoprotein-expressing cell lines. In the present study, we investigated the augmentation of DOX sensitivity by CEP using an MTT assay, and assessed the correlation between DOX sensitivity and P-glycoprotein expression by flow cytometry, in highly purified fresh human tumor cells obtained from 73 cancer patients. DOX sensitivity was decreased in proportion to P-glycoprotein expression. The cytotoxicity of DOX was increased by CEP in tumor cells possessing low DOX P-glycoprotein sensitivity. Moreover, there was a significant correlation between the effect of Doxorubicin CEP on cytotoxicity and P-glycoprotein expression. Thus, CEP might be able Cepharanthine to circumvent DOX resistance in cancer patients.
引用
收藏
页码：153 / 157
页数：5
相关论文
共 50 条
  • [21] Bioengineering approaches to study multidrug resistance in tumor cells
    Fallica, Brian
    Makin, Guy
    Zaman, Muhammad H.
    INTEGRATIVE BIOLOGY, 2011, 3 (05) : 529 - 539
  • [22] Modification of multidrug resistance of tumor cells by ionizing radiation
    Yuri N. Korystov
    Vera V. Shaposhnikova
    Antonina F. Korystova
    Maksim O. Emel’yanov
    Ludmila N. Kublik
    Cancer Chemotherapy and Pharmacology, 2008, 61 : 15 - 21
  • [23] Comparison of daunorubicin and Fluo-3 for detection of multidrug resistance in human tumor cells
    Gheuens, EEO
    vanderHeyden, SAM
    Elst, HE
    VanOosterom, AT
    DeBruijn, EA
    CANCER DETECTION AND PREVENTION, 1997, 21 (01): : 78 - 82
  • [24] Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids
    Molnár, J
    Gyémánt, N
    Mucsi, I
    Molnár, A
    Szabó, M
    Körtvélyesi, T
    Varga, A
    Molnár, P
    Tóth, G
    IN VIVO, 2004, 18 (02): : 237 - 244
  • [25] COMBINED EFFECTS OF BUTHIONINE SULFOXIMINE AND CEPHARANTHINE ON CYTOTOXIC ACTIVITY OF DOXORUBICIN TO MULTIDRUG-RESISTANT CELLS
    KISARA, S
    FURUSAWA, S
    MURATA, R
    OGATA, M
    HIKICHI, N
    TAKAYANAGI, Y
    SASAKI, KI
    ONCOLOGY RESEARCH, 1995, 7 (3-4) : 191 - 200
  • [26] Modulation of multidrug resistance (MDR) in hematological malignancies
    Covelli, A
    ANNALS OF ONCOLOGY, 1999, 10 : 53 - 59
  • [27] Reversal effect of Tween-20 on multidrug resistance in tumor cells in vitro
    Yang, Shouhui
    Liu, JinJuan
    Chen, Yongqiang
    Jiang, Jihong
    BIOMEDICINE & PHARMACOTHERAPY, 2012, 66 (03) : 187 - 194
  • [28] MULTIDRUG RESISTANCE IN HUMAN NEUROBLASTOMA-CELLS
    LAQUAGLIA, MP
    KOPP, EB
    SPENGLER, BA
    MEYERS, MB
    BIEDLER, JL
    JOURNAL OF PEDIATRIC SURGERY, 1991, 26 (09) : 1107 - 1112
  • [29] Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells
    Shiraki, N
    Okamura, K
    Tokunaga, J
    Ohmura, T
    Yasuda, K
    Kawaguchi, T
    Hamada, A
    Nakano, M
    JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (02): : 209 - 215
  • [30] Stilbenes as Multidrug Resistance Modulators and Apoptosis Inducers in Human Adenocarcinoma Cells
    Wesolowska, Olga
    Wisniewski, Jerzy
    Bielawska-Pohl, Aleksandra
    Paprocka, Maria
    Duarte, Noelia
    Ferreira, Maria-Jose U.
    Dus, Danuta
    Michalak, Krystyna
    ANTICANCER RESEARCH, 2010, 30 (11) : 4587 - 4593
12345