Non-invasive blood glucose measurement of 95% certainty by pressure regulated Mid-IR

被引:22
作者
Chen, Jason Yuanzhe [1 ]
Zhou, Qi
Xu, Gu [1 ,2 ]
Wang, Ryan Taoran [1 ]
Tai, Edward Guangqing [1 ]
Xie, Longhan [3 ]
Zhang, Qianzhi [4 ]
Guan, Yanyan [4 ]
Huang, Xiaochun [5 ]
机构
[1] McMaster Univ, Dept Mat Sci & Engn, 1280 Main St West, Hamilton, ON L8S 4L7, Canada
[2] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main ST W, Hamilton, ON L8S 4L1, Canada
[3] South China Univ Technol, 381 Wushan Rd, Guangzhou 510630, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R China
[5] Shantou Univ, 243 Univ Rd, Shantou 515021, Guangdong, Peoples R China
基金
加拿大自然科学与工程研究理事会;
关键词
Diabetes; Non-invasive; Glucose in vivo; Mid-infrared; Pressure Sensor; TEAR GLUCOSE; INFRARED-SPECTROSCOPY; POWER CALCULATIONS; SENSOR; NANOPARTICLES; BIOSENSOR; ELECTRODE; REMOVAL;
D O I
10.1016/j.talanta.2019.01.034
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
To fight against diabetes mellitus, from which more than 400 million people suffer in the world, the patients have to puncture their fingers 4-5 times a day for the blood glucose level checks when using a glucometer, causing invasive pain and the risk of infection. Therefore, non-invasive method has been urged for blood glucose monitoring, among which the mid-infrared spectroscopy (Mid-IR) response of interstitial fluid was found to be promising. However, despite the prolonged effort, the accuracy still falls below the FDA's requirement. To break this barrier which lasted for almost three decades, we discovered the finger contact pressure playing a critical role during the measurement, where the Mid-IR reading could be affected significantly by a small change of the finger posture. In addition, the Mid-IR absorption level was also found to be highly associated with individual, revealing the necessity of adjusting the calibration correlation for each patient. By imposing a certain contact pressure monitored by a pressure transducer, we were able to achieve over 95% certainty from the Mid-IR measurement of glucose concentration and 100% comparability to the "true" glucose concentration for the first time, which was mainly attributed to the morphological change of finger tissue under pressure. The previous works resulted in only about 70% accuracy on average, barely hitting 80 + %, whereas ours reaches 95%, finally exceeding the requirement of FDA.
引用
收藏
页码:211 / 217
页数:7
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