Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

被引：20

作者：

Zhang, Min ^{[1
]}

Cui, Xiuling ^{[1
]}

Chen, Xiaopei ^{[1
]}

Wang, Lianhui ^{[1
,2
]}

Li, Jingya ^{[2
]}

Wu, Yusheng ^{[2
]}

Hou, Lifen ^{[1
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China

[2] Tetranov Biopharm Inc, Zhengzhou 450052, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 03期

关键词：

Palladacycle; Suzuki cross-coupling; Cyclopropylboronic acid; Arylcyclopropane; CROSS-COUPLING REACTIONS; CYCLOPROPYLBORONIC ACID; ARYL HALIDES; CYCLOPALLADATED FERROCENYLIMINE; DERIVATIVES; CYCLOPROPANES; ALKYNES;

D O I：

10.1016/j.tet.2011.11.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sphos (2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl) adduct of cyclopalladated ferrocenylimine (Ile) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：900 / 905

页数：6

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