Repetitive transcranial magnetic stimulation and drug addiction

被引:56
作者
Barr, Mera S.
Farzan, Faranak [2 ,3 ]
Wing, Victoria C.
George, Tony P.
Fitzgerald, Paul B. [4 ]
Daskalakis, Zafiris J. [1 ]
机构
[1] Univ Toronto, Schizophrenia Program, Ctr Addict & Mental Hlth, Clarke Div, Toronto, ON, Canada
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Beth Israel Deaconess Med Ctr, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA
[4] Alfred & Monash Univ, Sch Psychol & Psychiat, Monash Alfred Psychiat Res Ctr, Melbourne, Australia
基金
加拿大健康研究院;
关键词
NATIONAL COMORBIDITY SURVEY; HUMAN MOTOR CORTEX; DORSOLATERAL PREFRONTAL CORTEX; GAMMA-AMINOBUTYRIC-ACID; NICOTINIC ACETYLCHOLINE-RECEPTORS; CULTURED CORTICAL-NEURONS; PLACEBO-CONTROLLED TRIAL; SUBSTANCE USE DISORDERS; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM;
D O I
10.3109/09540261.2011.618827
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that is now being tested for its ability to treat addiction. This review discusses current research approaches and results of studies which measured the therapeutic use of rTMS to treat tobacco, alcohol and illicit drug addiction. The research in this area is limited and therefore all studies evaluating the therapeutic use of rTMS in tobacco, alcohol or illicit drug addiction were retained including case studies through NCBI PubMed (http://www.ncbi.nlm.nih.gov) and manual searches. A total of eight studies were identified that examined the ability of rTMS to treat tobacco, alcohol and cocaine addiction. The results of this review indicate that rTMS is effective in reducing the level of cravings for smoking, alcohol, and cocaine when applied at high frequencies to the dorsolateral prefrontal cortex (DLPFC). Furthermore, these studies suggest that repeated sessions of high frequency rTMS over the DLPFC may be most effective in reducing the level of smoking and alcohol consumption. Although work in this area is limited, this review indicates that rTMS is a promising modality for treating drug addiction.
引用
收藏
页码:454 / 466
页数:13
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