Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment

被引：42
|
作者：
Wang, Jinghua [1 ]
Wang, Guangyou [1 ]
Sun, Bo [1 ]
Li, Hulun [1 ]
Mu, Lih [1 ]
Wang, Qi [1 ]
Li, Guozhong [2 ]
Shi, Lijun [3 ]
Jin, Lianhong [1 ]
Kostulas, Nikolaos [4 ]
机构：
[1] Harbin Med Coll, Dept Neurobiol, Heilongjiang 150081, Peoples R China
[2] Harbin Med Coll, Affiliated Clin Coll 1, Dept Neurol, Heilongjiang 150081, Peoples R China
[3] Harbin Med Coll, Affiliated Clin Coll 1, Dept Gastroenterol, Heilongjiang 150081, Peoples R China
[4] Huddinge Univ Hosp, Dept Neurol, S-14186 Huddinge, Sweden
来源：
JOURNAL OF AUTOIMMUNITY | 2008年 / 30卷 / 04期
关键词：
experimental autoimmune encephalomyelitis; bone marrow stromal cells; interleukin-17; interleukin-27; immunoregulation;
D O I：
10.1016/j.jaut.2007.10.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-17 is a key inflammatory cytokine in autoimmune disease and may play an important role in the development of experimental autoimmune encephalomyelitis (EAE). In this study, we observed decreased IL-17 and increased IL-27 in EAE rats treated with bone marrow stromal cells (BMSCs). Neutralization of IL-27 resulted in recovery of the BMSCs effect. Adoptive transfer induction of EAE was poor by BMSC-stimulated MNCs, but could be induced by MNCs stimulated by BMSCs under blockade of IL-27 signaling. These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：222 / 229
页数：8
相关论文
共 50 条
  • [1] Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice
    Zhang, Jing
    Li, Yi
    Lu, Mei
    Cui, Yisheng
    Chen, Jieli
    Noffsinger, Lori
    Elias, Stanton B.
    Chopp, Michael
    JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (03) : 587 - 595
  • [2] Bone marrow stromal cell therapy reduces proNGF and p75 expression in mice with experimental autoimmune encephalomyelitis
    Zhang, Jing
    Brodie, Chaya
    Li, Yi
    Zheng, Xuguang
    Roberts, Cynthia
    Lu, Mei
    Gao, Qi
    Borneman, Jade
    Savant-Bhonsale, Smita
    Elias, Stanton B.
    Chopp, Michael
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 279 (1-2) : 30 - 38
  • [3] Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation
    vanGelder, M
    vanBekkum, DW
    BONE MARROW TRANSPLANTATION, 1996, 18 (06) : 1029 - 1034
  • [4] Primaquine Treatment Suppresses Experimental Autoimmune Encephalomyelitis Severity
    Zanucoli, Fabio
    Thome, Rodolfo
    Bonfanti, Amanda Pires
    de Carvalho, Ana Carolina
    Issayama, Luidy K.
    da Costa, Thiago Alves
    Di Gangi, Rosaria
    Ferreira, Isadora Tassinari
    Bombeiro, Andre Luis
    Rodrigues de Oliveira, Alexandre Leite
    Verinaud, Liana
    CNS NEUROSCIENCE & THERAPEUTICS, 2014, 20 (12) : 1061 - 1064
  • [5] PRAZOSIN TREATMENT DURING THE EFFECTOR STAGE OF DISEASE SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE LEWIS RAT
    BROSNAN, CF
    SACKS, HJ
    GOLDSCHMIDT, RC
    GOLDMUNTZ, EA
    NORTON, WT
    JOURNAL OF IMMUNOLOGY, 1986, 137 (11): : 3451 - 3456
  • [6] Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis
    Chiuso-Minicucci, Fernanda
    Watanabe Ishikawa, Larissa Lumi
    Nishiyama Mimura, Luiza Ayumi
    de Campos Fraga-Silva, Thais Fernanda
    Donega Franca, Thais Graziela
    Fernanda Goncalves Zorzella-Pezavento, Sofia
    Marques, Camila
    Valerio Ikoma, Maura Rosane
    Sartori, Alexandrina
    PLOS ONE, 2015, 10 (05):
  • [7] INTERLEUKIN-33 IS RELEASED IN SPINAL CORD AND SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN MICE
    Chen, H.
    Sun, Y.
    Lai, L.
    Wu, H.
    Xiao, Y.
    Ming, B.
    Gao, M.
    Zou, H.
    Xiong, P.
    Xu, Y.
    Tan, Z.
    Gong, F.
    Zheng, F.
    NEUROSCIENCE, 2015, 308 : 157 - 168
  • [8] Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis
    Gilgun-Sherki, Y
    Panet, H
    Melamed, E
    Offen, D
    BRAIN RESEARCH, 2003, 989 (02) : 196 - 204
  • [9] Plumbagin suppresses dendritic cell functions and alleviates experimental autoimmune encephalomyelitis
    Zhang, Kai
    Ge, Zhenzhen
    Da, Yurong
    Wang, Dong
    Liu, Ying
    Xue, Zhenyi
    Li, Yan
    Li, Wen
    Zhang, Lijuan
    Wang, Huafeng
    Zhang, Huan
    Peng, Meiyu
    Hao, Junwei
    Yao, Zhi
    Zhang, Rongxin
    JOURNAL OF NEUROIMMUNOLOGY, 2014, 273 (1-2) : 42 - 52
  • [10] Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation
    vanGelder, M
    Mulder, AH
    vanBekkum, DW
    TRANSPLANTATION, 1996, 62 (06) : 810 - 818
12345