Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma

被引：18

作者：

Tan, Ying ^{[1
]}

Li, Bijuan ^{[1
]}

Peng, Fang ^{[2
]}

Gong, Guanghui ^{[3
]}

Li, Ning ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Blood Transfus, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp, NHC Key Lab Canc Prote, Changsha, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

基金：

中国国家自然科学基金;

关键词：

sirtuins; epigenetics; TCGA; cancer; clear cell renal cell carcinoma; TUMOR-SUPPRESSOR; CANCER; EXPRESSION; SIRT6; SURVIVAL; PROLIFERATION; RESISTANCE; GROWTH;

D O I：

10.3389/fonc.2020.00218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sirtuins, class III histone deacetylases, are involved in multiple biological processes in cancer initiation and progression. However, the diverse expression patterns and prognostic values of sirtuins in cancers have yet to be elucidated. In this study, we first evaluated the expression and prognostic values of sirtuins in multiple cancer cohorts using publicly available TCGA pan-cancer datasets. Pan-cancer survival analysis indicated that 6 out of 7 sirtuin family members were significant associated with prognosis of clear cell renal cell carcinoma (KIRC) patients. SIRT1, SIRT3, SIRT4, and SIRT5 were associated with favorable prognosis of KIRC patients, while SIRT6 and SIRT7 were associated with unfavorable prognosis. The expression levels of SIRT4 and SIRT5 in KIRC tissues were lower than that in normal tissues, while SIRT6 and SIRT7 were higher in KIRC tissues. The expression levels of SIRT1, SIRT3, SIRT5, SIRT6, and SIRT7 were significantly correlated with tumor stage and histological grade. DNA methylation may contribute to the dysregulation of sirtuins. Finally, GSEA was conducted to predict the potential functions of sirtuins in KIRC. Our results may provide novel insights for the development of sirtuins-based cancer therapy in KIRC.

引用

页数：10

共 50 条

[11] Comprehensivemolecular characterization of clear cell renal cell carcinoma [J].

Creighton, Chad J. ;

Morgan, Margaret ;

Gunaratne, Preethi H. ;

Wheeler, David A. ;

Gibbs, Richard A. ;

Robertson, A. Gordon ;

Chu, Andy ;

Beroukhim, Rameen ;

Cibulskis, Kristian ;

Signoretti, Sabina ;

Vandin, Fabio ;

Wu, Hsin-Ta ;

Raphael, Benjamin J. ;

Verhaak, Roel G. W. ;

Tamboli, Pheroze ;

Torres-Garcia, Wandaliz ;

Akbani, Rehan ;

Weinstein, John N. ;

Reuter, Victor ;

Hsieh, James J. ;

Brannon, A. Rose ;

Hakimi, A. Ari ;

Jacobsen, Anders ;

Ciriello, Giovanni ;

Reva, Boris ;

Ricketts, Christopher J. ;

Linehan, W. Marston ;

Stuart, Joshua M. ;

Rathmell, W. Kimryn ;

Shen, Hui ;

Laird, Peter W. ;

Muzny, Donna ;

Davis, Caleb ;

Morgan, Margaret ;

Xi, Liu ;

Chang, Kyle ;

Kakkar, Nipun ;

Trevino, Lisa R. ;

Benton, Susan ;

Reid, Jeffrey G. ;

Morton, Donna ;

Doddapaneni, Harsha ;

Han, Yi ;

Lewis, Lora ;

Dinh, Huyen ;

Kovar, Christie ;

Zhu, Yiming ;

Santibanez, Jireh ;

Wang, Min ;

Hale, Walker .

NATURE, 2013, 499 (7456) :43-+

[12] Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [J].

Ferlay, Jacques ;

Soerjomataram, Isabelle ;

Dikshit, Rajesh ;

Eser, Sultan ;

Mathers, Colin ;

Rebelo, Marise ;

Parkin, Donald Maxwell ;

Forman, David ;

Bray, Freddie .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E359-E386

[13] MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1 [J].

Fu, Hao ;

Song, Wenke ;

Chen, Xuancai ;

Guo, Tao ;

Duan, Bin ;

Wang, Xinxi ;

Tang, Yachun ;

Huang, Liang ;

Zhang, Chi .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2018, 437 (1-2) :143-152

[14] Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal [J].

Gao, Jianjiong ;

Aksoy, Buelent Arman ;

Dogrusoz, Ugur ;

Dresdner, Gideon ;

Gross, Benjamin ;

Sumer, S. Onur ;

Sun, Yichao ;

Jacobsen, Anders ;

Sinha, Rileen ;

Larsson, Erik ;

Cerami, Ethan ;

Sander, Chris ;

Schultz, Nikolaus .

SCIENCE SIGNALING, 2013, 6 (269) :pl1

[15]

Garcia-Peterson Liz Mariely, 2017, Genes Cancer, V8, P701, DOI 10.18632/genesandcancer.153

[16] Sirtuins, Aging, and Medicine [J].

Guarente, Leonard .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (23) :2235-2244

[17] The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1 [J].

Hou, Zhouhua ;

Xu, Xuwen ;

Zhou, Ledu ;

Fu, Xiaoyu ;

Tao, Shuhui ;

Zhou, Jiebin ;

Tan, Deming ;

Liu, Shuiping .

TUMOR BIOLOGY, 2017, 39 (07) :1-11

[18] Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer [J].

Huang, Guoyu ;

Zhu, Guanbao .

ONCOTARGETS AND THERAPY, 2018, 11 :3395-3400

[19] Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase [J].

Imai, S ;

Armstrong, CM ;

Kaeberlein, M ;

Guarente, L .

NATURE, 2000, 403 (6771) :795-800

[20] Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance [J].

Jeh, Seong Uk ;

Park, Jung Je ;

Lee, Jong Sil ;

Kim, Dong Chul ;

Do, Jungmo ;

Lee, Sin Woo ;

Choi, See Min ;

Hyun, Jae Seog ;

Seo, Deok Ha ;

Lee, Chunwoo ;

Kam, Sung Chul ;

Chung, Ky Hyun ;

Hwa, Jeong Seok .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2017, 35 (12) :675.e9-675.e15

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