A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides

被引：31

作者：

Burg, Finn ^{[1
,2
]}

Egger, Julian ^{[1
]}

Deutsch, Johannes ^{[1
]}

Guimond, Nicolas ^{[1
]}

机构：

[1] Bayer Pharma AG, Chem Dev Dept, Friedrich Ebert Str 217-333, D-42096 Wuppertal, Germany

[2] Univ Munich, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2016年 / 20卷 / 08期

关键词：

MEDIATED CYANATION; METAL-FREE; BROMIDES; SYSTEM; CHLORIDES; PHARMACEUTICALS; HALOARENES; CLEAVAGE; CYANIDE; AGENT;

D O I：

10.1021/acs.oprd.6b00229

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Homogeneous conditions for the palladium-catalyzed cyanation of aryl halides were developed. This new system features a broad scope of aryl chlorides and bromides, uses 2-propanol or 1-butanol as solvent, and is readily scalable. The same conditions can also provide simple benzonitriles using the recently developed (TMEDA)NiCl(o-tolyl) precatalyst in conjunction with 1,1'-bis(diphenylphosphino)ferrocene (dppf) as a ligand.

引用

页码：1540 / 1545

页数：6

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