Expression of sex hormone receptors in the brain of male and female newly hatched chicks

被引:5
|
作者
Camacho-Arroyo, Ignacio [1 ]
Hansberg-Pastor, Valeria [2 ]
Gutierrez-Rodriguez, Araceli [1 ]
Chavez-Jimenez, Jorge [1 ]
Genoveva Gonzalez-Moran, Maria [3 ]
机构
[1] UNAM, Fac Quim, Inst Nacl Perinatol, Unidad Invest Reprod Humana, Ciudad De Mexico, Mexico
[2] UNAM, Dept Biol, Fac Quim, Ciudad De Mexico, Mexico
[3] UNAM, Fac Ciencias, Dept Biol Comparada, Lab Biol Reprod Anim, Ciudad De Mexico, Mexico
关键词
Sex hormone receptors; Newly hatched chicks; Brain; Sexual dimorphism; NUCLEAR PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTORS; JAPANESE-QUAIL; MESSENGER-RNA; AVIAN BRAIN; ISOFORMS; HYPOTHALAMUS; ANDROGEN; ALPHA; CELLS;
D O I
10.1016/j.anireprosci.2017.11.016
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Chromosomal sex and steroid hormones play a determining role in brain sexual differentiation during chick embryonic development. Hormone effects on the brain are associated with the expression pattern of their intracellular receptors, which is sexually dimorphic in many species. We determined by Western blot the content of progesterone, estrogen, and androgen receptors (PR-A and PR-B, ER alpha, and AR, respectively) in the cortex, cerebellum, tectum, and hypothalamus of female and male newly hatched chicks. Males presented a higher content of PR-B in the tectum whereas females exhibited a higher content of PR-A in the hypothalamus. ER alpha was only detected as a band of 66 kDa, and it showed a higher content in the cerebellum and tectum of females as compared to these regions in males. Besides, males exhibited a higher content of AR in the tectum than females. Our study suggests that newly hatched chicks show a sexual dimorphism in the expression of sex hormone receptors in brain regions involved in sexual behavior such as the hypothalamus, and in non-sexual behavior such as the optic tectum and the cerebellum.
引用
收藏
页码:123 / 129
页数:7
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