Gold-Catalyzed Cycloisomerization of Functionalized 1,5-Enynes - An Entry to Polycyclic Framework

被引：25

作者：

Pradal, Alexandre ^{[1
,2
]}

Chen, Qian ^{[1
,2
]}

Bel, Pierre Faudot Dit ^{[1
,2
]}

Toullec, Patrick Yves ^{[1
,2
]}

Michelet, Veronique ^{[1
,2
]}

机构：

[1] Chim ParisTech, LCF, F-75231 Paris 05, France

[2] CNRS, UMR 7223, F-75231 Paris 05, France

来源：

SYNLETT | 2012年 / 23卷 / 01期

关键词：

gold catalyst; cycloisomerization; 1,5-enynes; atom economy; polycyclization; ACETYLENIC CARBOXYLIC-ACIDS; EFFICIENT ACCESS; HIGHLY EFFICIENT; SELECTIVE CYCLOISOMERIZATION; GOLD(I)-CATALYZED SYNTHESIS; ELECTROPHILIC ACTIVATION; INTERMOLECULAR ADDITION; PLATINUM CATALYSIS; ENYNES; CYCLIZATION;

D O I：

10.1055/s-0031-1289867

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The gold-catalyzed cycloisomerization reactions of variously functionalized 1,5-enynes are presented. The cyclization processes implying aryl-and 1,3-dicarbonyl-substituted skeletons are conducted under mild conditions and lead to cyclic structures obtained according to 6-endo-dig or 5-endo-dig mode depending on the involved nucleophilic partner. Some competitive pathways and trapping of carbocationic intermediates are highlighted.

引用

页码：74 / 79

页数：6

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