Enantioselective and Regioselective Indium(III)-Catalyzed Addition of Pyrroles to Isatins

被引：45
作者：
Gutierrez, Elisa G. [1 ]
Wong, Casey J. [1 ]
Sahin, Aziza H. [1 ]
Franz, Annaliese K. [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 21期
关键词：
CARBONYL-ENE REACTIONS; IN(III)-PYBOX COMPLEX; LIGANDS; DERIVATIVES; OXINDOLES;
D O I：
10.1021/ol202329s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The indium(III)-catalyzed enantioselective and regioselective addition of pyrroles to isatins is described. The effects of metal and solvent on the reactivity and selectivity are compared and discussed, demonstrating that the indium(III)-indapybox complex provides the most effective catalyst. A case of divergent reactivity between pyrroles and indoles is presented.
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收藏
页码：5754 / 5757
页数：4
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