Isolation and anticomplement activity of compounds from Dendropanax morbifera

被引：78

作者：

Park, BY

Min, BS

Oh, SR

Kim, JH

Kim, TJ

Kim, DH

Bae, KH

Lee, HK ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Lab Immunomodulator, Taejon 305600, South Korea

[2] Deajeon Univ, Coll Oriental Med, Pathol Lab, Taejon 300176, South Korea

[3] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 2-3期

关键词：

Dendropanax morbifera Leveille; anticomplement activity; (9Z,16S)-16-Hydroxy-9,17-octadecadiene-12,14-diynoic acid; polyacetylene;

D O I：

10.1016/j.jep.2003.11.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrheal. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z, 16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. Of these, compound I showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98 muM, whereas compounds 2-7 were inactive. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：403 / 408

页数：6

共 27 条

[11]

Jung KY, 1998, BIOL PHARM BULL, V21, P1077, DOI 10.1248/bpb.21.1077

[12]

KANG SS, 1987, KOREAN J PHARMACOGN, V18, P151

[13]

KAWAZU K, 1973, Tetrahedron Letters, V33, P3131

[14] Controlling the complement system in inflammation [J].