Repeatability of Radiomic Features in Non-Small-Cell Lung Cancer [18F]FDG-PET/CT Studies: Impact of Reconstruction and Delineation

被引：218
作者：
van Velden, Floris H. P. [1 ,2 ]
Kramer, Gerbrand M. [1 ]
Frings, Virginie [1 ]
Nissen, Ida A. [1 ]
Mulder, Emma R. [1 ]
de Langen, Adrianus J. [3 ]
Hoekstra, Otto S. [1 ]
Smit, Egbert F. [3 ,4 ]
Boellaard, Ronald [1 ,5 ]
机构：
[1] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, POB 7057, NL-1007 MB Amsterdam, Netherlands
[2] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands
[3] Vrije Univ Amsterdam, Dept Pulm Dis, Med Ctr, Amsterdam, Netherlands
[4] Netherlands Canc Inst, Dept Thorac Oncol, Amsterdam, Netherlands
[5] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands
来源：
MOLECULAR IMAGING AND BIOLOGY | 2016年 / 18卷 / 05期
关键词：
PET/CT; Repeatability; Radiomics; Tracer uptake heterogeneity; Non-small-cell lung cancer (NSCLC); TUMOR TEXTURE ANALYSIS; QUANTITATIVE FDG-PET; F-18-FDG PET; UPTAKE HETEROGENEITY; FRACTAL ANALYSIS; UPTAKE VALUES; TEST-RETEST; VOLUME; IMAGES; CHEMORADIOTHERAPY;
D O I：
10.1007/s11307-016-0940-2
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
To assess (1) the repeatability and (2) the impact of reconstruction methods and delineation on the repeatability of 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies. Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using the point spread function (PSF) and once complying with the European Association for Nuclear Medicine (EANM) guidelines for tumor PET imaging. Volumes of interest (n = 19) were delineated twice, once on PET and once on CT images. Sixty-three features showed an intraclass correlation coefficient aeyen 0.90 independent of delineation or reconstruction. More features were sensitive to a change in delineation than to a change in reconstruction (25 and 3 features, respectively). The majority of features in NSCLC [F-18]FDG-PET/CT studies show a high level of repeatability that is similar or better compared to simple standardized uptake value measures.
引用
收藏
页码：788 / 795
页数：8
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